State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Fitoterapia. 2020 Apr;142:104487. doi: 10.1016/j.fitote.2020.104487. Epub 2020 Jan 24.
Two new tetrahydrobenzocyclooctabenzofuranone lignans (1-2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4-6), together with six known compounds (7-12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%.
从长梗南五味子的根部分离得到两个新的四氢苯并环辛二烯木脂素（1-2）、一个新的二苯并环辛二烯木脂素（3）和三个新的石竹烷型三萜（4-6），以及六个已知化合物（7-12）。通过广泛的 NMR 和 HRESIMS 光谱数据分析阐明了它们的结构。通过比较实验和计算的 ECD 光谱确定了这些化合物的绝对构型。化合物 12 对 N-乙酰对氨基酚（APAP）诱导的 HepG2 细胞毒性表现出中等的肝保护活性，细胞存活率为 53.04%。
