长梗南五味子中二氢苯并呋喃并色原酮和二苯并环辛二烯型木脂素的保肝作用。
Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata.
机构信息
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy , Medical University of South Carolina , Charleston , South Carolina 29425 , United States.
出版信息
J Nat Prod. 2018 Apr 27;81(4):846-857. doi: 10.1021/acs.jnatprod.7b00934. Epub 2018 Mar 29.
Five new dibenzocyclooctadiene lignans, longipedlignans A-E (1-5), five new tetrahydrobenzocyclooctabenzofuranones (6-10), and 18 known analogues (11-28) were isolated from the roots of Kadsura longipedunculata. Compounds 6-10 are new spirobenzofuranoid-dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl- p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.
从长梗南五味子的根部分离得到了五个新的二苯并环辛二烯木脂素，长叶木脂素 A-E（1-5），五个新的四氢苯并环辛并苯并呋喃酮（6-10），以及 18 个已知类似物（11-28）。化合物 6-10 是新的螺苯并呋喃并二苯并环辛二烯型木脂素。它们的结构和绝对构型是通过 MS、NMR 和电子圆二色谱数据的组合确定的。螺苯并呋喃酮 6 和 15 在 10 μM 时对 N-乙酰对氨基酚诱导的 HepG2 细胞毒性具有中等的肝保护活性，细胞存活率分别为 52.2%和 50.2%。
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