State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy , Medical University of South Carolina , Charleston , South Carolina 29425 , United States.
J Nat Prod. 2018 Apr 27;81(4):846-857. doi: 10.1021/acs.jnatprod.7b00934. Epub 2018 Mar 29.
Five new dibenzocyclooctadiene lignans, longipedlignans A-E (1-5), five new tetrahydrobenzocyclooctabenzofuranones (6-10), and 18 known analogues (11-28) were isolated from the roots of Kadsura longipedunculata. Compounds 6-10 are new spirobenzofuranoid-dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl- p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.
从长梗南五味子的根部分离得到了五个新的二苯并环辛二烯木脂素，长叶木脂素 A-E（1-5），五个新的四氢苯并环辛并苯并呋喃酮（6-10），以及 18 个已知类似物（11-28）。化合物 6-10 是新的螺苯并呋喃并二苯并环辛二烯型木脂素。它们的结构和绝对构型是通过 MS、NMR 和电子圆二色谱数据的组合确定的。螺苯并呋喃酮 6 和 15 在 10 μM 时对 N-乙酰对氨基酚诱导的 HepG2 细胞毒性具有中等的肝保护活性，细胞存活率分别为 52.2%和 50.2%。
