通过 HDDA 偶联法获得苯并恶嗪和全取代吲哚。
Access to Benzoxazepines and Fully Substituted Indoles via HDDA Coupling.
机构信息
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, State Laboratory Cultivation Base, College of Chemistry and Materials Science , Anhui Normal University , Wuhu , Anhui 241002 , China.
出版信息
Org Lett. 2020 Feb 7;22(3):956-959. doi: 10.1021/acs.orglett.9b04499. Epub 2020 Jan 28.
The HDDA-derived benzyne intermediate was captured by oxazolines based on the addition reaction of benzyne to the C═N double bond. Benzoxazepine derivatives, fused benzoxazepine derivatives, and fully substituted indoles are synthesized in one step. The reaction does not require any catalyst or additives. Possible reaction mechanisms are presented.
HDDA 衍生的苯炔中间体通过苯炔与 C=N 双键的加成反应被恶唑啉捕获。一步合成苯并噁嗪衍生物、稠合苯并噁嗪衍生物和全取代吲哚。反应不需要任何催化剂或添加剂。提出了可能的反应机制。
Zotero 插件