ω-3 干预酒精依赖及相关结局：系统评价与建议。
OMEGA-3 Interventions in Alcohol Dependence and Related Outcomes: A Systematic Review and Propositions.
机构信息
Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
出版信息
Curr Neuropharmacol. 2020;18(5):456-462. doi: 10.2174/1570159X18666200128120729.
BACKGROUND
Pharmacological treatment for alcohol dependence has only three approved drugs: disulfiram, naltrexone and acamprosate. The effects of these drugs are, however, limited, presenting several side effects and a modestly higher efficacy compared to placebo. The administration of omega-3 might bring new perspectives to relapse prevention.
METHODS
This systematic review aimed to analyze the available literature, compiling the studies that used omega-3 to prevent relapse in alcohol dependents.
RESULTS
The databases used were PubMed and Web of Science. We identified 2,231 studies and only five articles addressed the administration of omega-3 and alcoholism. Preclinical studies evaluating the effects of PUFAs related to chronic alcohol administration showed improvements in behavioral, cellular and molecular levels. The clinical trial yielded inconclusive results.
CONCLUSION
Despite the reduced number of studies, omega-3 interventions seem to be promising for controlling issues related to alcohol dependence.
背景
酒精依赖的药物治疗仅有三种获得批准的药物：双硫仑、纳曲酮和安非他酮。然而，这些药物的效果有限，与安慰剂相比，它们会带来更多副作用，且疗效也只是略高。ω-3 的给药可能为预防复发带来新视角。
方法
本系统评价旨在分析现有文献，汇编使用 ω-3 预防酒精依赖者复发的研究。
结果
使用的数据库为 PubMed 和 Web of Science。我们共检索到 2231 项研究，仅有 5 项文章涉及 ω-3 与酒精中毒的给药。评估慢性酒精给药相关多不饱和脂肪酸作用的临床前研究显示，在行为、细胞和分子水平上有改善。临床试验得出的结果并不确定。
结论
尽管研究数量较少，但 ω-3 干预似乎有望控制与酒精依赖相关的问题。
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