No. 5 Clinical Department, Third Hospital of Lanzhou City, Lanzhou, China.
Clinical Laboratory, Third Hospital of Lanzhou City, Lanzhou, China.
Medicine (Baltimore). 2022 Sep 9;101(36):e30459. doi: 10.1097/MD.0000000000030459.
Alcohol dependence (AD) syndrome refers to a strong addiction to alcohol and high tolerance physiologically or psychologically, due to the repeated consumption of alcohol-based substances. This study aimed to examine the efficacy of group cognitive behavioral therapy (GCBT) on patients with AD. A total of 128 patients with AD were randomly assigned to the GCBT or control group. Patients in the GCBT group underwent an 8-week GCBT in addition to conventional treatment, and patients in the control group only received conventional treatment. The insight and treatment attitude questionnaire (ITAQ) score, chronic disease self-cognition evaluation score (CDSCES), treatment adherence, and relapse rate at 6 and 12 months were compared among the 2 groups. The ITAQ scores of the GCBT group, after treatment, increased significantly compared to those of the control group (19.69% vs 13.26%, P < .001). The CDSCES in the GCBT group increased significantly compared to those in the control group after treatment (3.98 vs 2.18, P = .001 for problem-solving ability; 8.08 vs 5.08, P = .001 for self-management efficacy; 4.29 vs 3.30, P = .005 for a positive response, and 4.84 vs 3.44, P = .008 for a social function, respectively). After treatment, the percentage of patients with AD with full compliance in the GCBT group was much higher than in the control group (93.8% vs 65.6%, P < .001). Contrastingly, the percentage of patients with AD with partial compliance in the GCBT group was much lower than that in the control group (3.2% vs 34.4%, P < .001). The relapse rate (%) of drinking in patients with AD in the GCBT group was much lower than that in the control group (1.56% vs 21.8%, P = .001 for 6 months and 4.7% vs 51.6%, P < .001 for 12 months). The results suggest that GCBT for 8 weeks is an effective approach for patients with AD, improving problem-solving ability, self-management efficacy, positive response, and social function, leading to increase in treatment compliance, and reducing relapse rate.
酒精依赖（AD）综合征是指由于反复摄入含酒精物质，导致生理或心理上对酒精产生强烈的依赖和高度的耐受性。本研究旨在探讨团体认知行为疗法（GCBT）对 AD 患者的疗效。将 128 例 AD 患者随机分为 GCBT 组和对照组。GCBT 组患者除常规治疗外，还接受 8 周的 GCBT，对照组患者仅接受常规治疗。比较两组患者的洞察和治疗态度问卷（ITAQ）评分、慢性病自我认知评价量表（CDSCES）评分、治疗依从性和 6 个月及 12 个月时的复发率。GCBT 组治疗后 ITAQ 评分明显高于对照组（19.69%比 13.26%，P<0.001）。GCBT 组治疗后 CDSCES 中解决问题能力评分（3.98 分比 2.18 分，P=0.001）、自我管理效能感评分（8.08 分比 5.08 分，P=0.001）、积极应对评分（4.29 分比 3.30 分，P=0.005）和社会功能评分（4.84 分比 3.44 分，P=0.008）明显高于对照组。治疗后，GCBT 组完全依从的 AD 患者比例明显高于对照组（93.8%比 65.6%，P<0.001），部分依从的 AD 患者比例明显低于对照组（3.2%比 34.4%，P<0.001）。GCBT 组 AD 患者的饮酒复发率（%）明显低于对照组（6 个月时为 1.56%比 21.8%，P=0.001；12 个月时为 4.7%比 51.6%，P<0.001）。结果表明，GCBT 治疗 8 周是 AD 患者的有效治疗方法，可提高患者解决问题的能力、自我管理效能感、积极应对和社会功能，提高治疗依从性，降低复发率。
