Veterinary Public Health Institute of Sardinia - Lab. Control of Animal Origin Food, Via Ducda degli Abruzzi 8, 07100, Sassari, Italy.
Fondazione Centro Ricerche Marine, National Reference Laboratory for Marine Biotoxins, V.le A. Vespucci 2, 47042, Cesenatico (FC), Italy.
Toxicon. 2020 Jan 30;174:48-56. doi: 10.1016/j.toxicon.2019.12.157. Epub 2019 Dec 24.
Paralytic shellfish poisoning is a human intoxication syndrome associated with the consumption of seafood that has been contaminated with paralytic shellfish toxins (PSTs), a group of natural neurotoxic alkaloids produced by marine dinoflagellates, including some Alexandrium species. This study presents findings of PSTs in mussels (Mytilus galloprovincialis) during 2018-2019 in several mollusc production areas of Sardinia (Italy, western Mediterranean). Investigations of the presence and abundance of PST-producing microalgal species in marine water and of the toxins associated with shellfish were carried out concomitantly. Overall, the results suggested a spatio-temporal expansion of Alexandriumpacificum and Alexandriumminutum in recent years, with an increasing number of PSTs present in molluscs and increased occurrences of toxicity cases. Liquid chromatography with fluorescence detection determined the toxin profile to be composed primarily of the carbamate gonyautoxin-5 and N-sulphocarbamoyltoxins 1 and 2. The study highlights the potential high risk to consumers of poisoning by bivalve molluscs bred in Sardinia, where shellfish production is a very important industrial sector. For this reason, routine monitoring is strongly recommended in order to mitigate any harm to human health as well as negative socio-economic consequences.
麻痹性贝类毒素中毒是一种与食用受麻痹性贝类毒素（PSTs）污染的海鲜有关的人类中毒综合征，PSTs 是一组天然神经毒性生物碱，由海洋甲藻产生，包括一些亚历山大藻属物种。本研究报告了 2018-2019 年在意大利西部地中海的几个贻贝生产区中贻贝（Mytilus galloprovincialis）中 PSTs 的含量。同时对海洋水中产毒微藻种类的存在和丰度以及与贝类相关的毒素进行了调查。总体而言，结果表明近年来亚历山大藻和亚历山大微藻在空间和时间上的扩张，贝类中存在的 PSTs 数量增加，毒性事件的发生频率也增加。采用荧光检测的液相色谱法确定毒素谱主要由氨基甲酸酯 GTX-5 和 N-磺酰基氨甲酰基毒素 1 和 2 组成。该研究强调了在贝类生产是一个非常重要的工业部门的撒丁岛，食用养殖的双壳类贝类可能对消费者造成高中毒风险。因此，强烈建议进行常规监测，以减轻对人类健康以及负面社会经济后果的任何危害。
