van Heerden M R, Cole K, van der Meulen N P, Franzidis J-P, Buffler A
Minerals to Metals Research Initiative, University of Cape Town, Rondebosch, 7701, South Africa; Department of Physics, University of Cape Town, Rondebosch, 7701, South Africa.
Department of Physics, University of Cape Town, Rondebosch, 7701, South Africa.
Appl Radiat Isot. 2020 Apr;158:109044. doi: 10.1016/j.apradiso.2020.109044. Epub 2020 Jan 17.
The SnOGe/Ga generator system is widely used in medical imaging to provide a regular supply of the radionuclide Ga (T = 68.3 min) for positron emission tomography (PET). These generators are also used to supply Ga for the fabrication of tracer particles for application in positron emission particle tracking (PEPT). The tracer particles are fabricated by radiolabelling ion exchange resins such as Purolite NRW100 with Ga; however, contaminants from the degradation of the SnO column over time interfere with the uptake of Ga. The major contaminants are Zn(II), Fe(III) and Sn(IV) with Ge (IV) being eluted from the column as it degrades. This paper describes an improved method to purify the Ga supply using an Amberchrom CG-71m absorption resin column integrated into a newly designed separation panel. This method reduces the amount of Zn(II) and Fe(III) in the Ga eluate and improves the radiolabelling performance by more than 10% when compared to the un-purified product. The method can extend the life-span of the generator by several months.
SnOGe/Ga发生器系统广泛应用于医学成像领域，用于为正电子发射断层扫描（PET）定期供应放射性核素Ga（半衰期T = 68.3分钟）。这些发生器还用于为制造用于正电子发射粒子跟踪（PEPT）的示踪剂颗粒提供Ga。示踪剂颗粒是通过用Ga对离子交换树脂（如Purolite NRW100）进行放射性标记来制备的；然而，随着时间的推移，SnO柱降解产生的污染物会干扰Ga的摄取。主要污染物是Zn(II)、Fe(III)和Sn(IV)，随着柱的降解，Ge(IV)也会从柱中洗脱出来。本文描述了一种改进的方法，该方法使用集成在新设计的分离板中的Amberchrom CG-71m吸附树脂柱来纯化Ga供应。与未纯化的产品相比，该方法减少了Ga洗脱液中Zn(II)和Fe(III)的含量，并将放射性标记性能提高了10%以上。该方法可以将发生器的使用寿命延长几个月。
