Grundmane Aivija, Dovhyi Illarion, Aburto-Kung Lauren, Happel Steffen, Ramogida Caterina F, Radchenko Valery
Department of Chemistry, Simon Fraser University, 8888 University Dr W, Burnaby, BC, V5A 1S6, Canada.
Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3, Canada.
EJNMMI Radiopharm Chem. 2025 Aug 13;10(1):53. doi: 10.1186/s41181-025-00379-y.
Antimony-119 (Sb, t = 38.19 h) is an Auger electron emitting radionuclide of interest for radiopharmaceutical therapy. It can be directly produced by proton bombardment of tin-119 using low energy cyclotrons. The radiochemical separation methods available for recovering Sb from the bulk Sn target material are lacking, particularly with respect to matrix suitability for further applications.
Eight new resins were successfully synthesized, evaluating combinations of two different resin support materials with three different chain lengths of ethers (dibutyl, dipentyl, dioctyl) as well as fluorinated alcohol as the impregnated extractant. All resins showed good stability, losing less than 1% of functional groups in HCl and water. Seven out of eight synthesized resins showed excellent capacity, retaining tens to hundreds of milligrams of Sb per gram of resin. Seven out of eight synthesized resins, as well as one of the resin supports showed good separation between Sb and Sn based on the distribution coefficient studies as well as dynamic elution studies.
Our tested resins may be applied for the separation of radiotracer amounts of Sb from bulk Sn target material. We propose the dibutyl ether functionalized divinylbenzene copolymer resin support (DBE-300 resin) as the best candidate, based on the following characteristics: (1) quantitative, concentrated elution of Sn offering compatibility with recycling of enriched Sn material; (2) near-quantitative (98%), concentrated recovery of Sb in ethanol, providing a matrix resistant to hydrolysis, easy to convert by evaporation, as well as toxicologically insignificant pre-clinically and even clinically.
The online version contains supplementary material available at 10.1186/s41181-025-00379-y.
锑 - 119（¹¹⁹Sb，半衰期t = 38.19小时）是一种用于放射性药物治疗的俄歇电子发射放射性核素。它可以通过使用低能回旋加速器对锡 - 119进行质子轰击直接产生。目前缺乏从大量锡靶材料中回收¹¹⁹Sb的放射化学分离方法，特别是在基质对进一步应用的适用性方面。
成功合成了八种新型树脂，评估了两种不同树脂载体材料与三种不同链长的醚（二丁基、二戊基、二辛基）以及氟化醇作为浸渍萃取剂的组合。所有树脂均表现出良好的稳定性，在盐酸和水中官能团损失小于1%。八种合成树脂中的七种表现出优异的容量，每克树脂可保留数十至数百毫克的¹¹⁹Sb。基于分配系数研究和动态洗脱研究，八种合成树脂中的七种以及其中一种树脂载体在¹¹⁹Sb和Sn之间表现出良好的分离效果。
我们测试的树脂可用于从大量锡靶材料中分离放射性示踪量的¹¹⁹Sb。基于以下特性，我们提出二丁基醚官能化的二乙烯基苯共聚物树脂载体（DBE - 300树脂）作为最佳候选：（1）锡的定量、浓缩洗脱，与富集锡材料的回收兼容；（2）在乙醇中¹¹⁹Sb近乎定量（98%）的浓缩回收，提供抗水解的基质，易于通过蒸发转化，并且在临床前甚至临床毒理学上无显著影响。
在线版本包含可在10.1186/s41181 - 025 - 00379 - y获取的补充材料。
