Stumpf Tamás, Mattsson Gustav, Magnusson Peter
Region Jönköpings län - Länssjukhuset Ryhov Jönköping, Sweden Region Jönköpings län - Länssjukhuset Ryhov Jönköping, Sweden.
Uppsala Universitet, Centrum för forskning och utveckling, Region Gävleborg, Gävle, Sweden.
Lakartidningen. 2020 Jan 24;117:FSS7.
Peripartum cardiomyopathy is defined as heart failure, with ejection fraction less than 45% that presents late during pregnancy or the first five months postpartum. Despite being described first in 1849 by Ritchie the mechanisms behind the disease are still not fully understood. However, oxidative stress during pregnancy and the cleavage of prolactine into its 16 kDa fragment appears to play a role in the pathophysiology of peripartum cardiomyopathy. In addition to optimal therapy for heart failure bromocriptine, an inhibitor of prolactine release, should be considered. Prevalence and prognosis varies geographically. Most often left ventricular ejection fraction is normalized after six months but sometimes the disease is associated with deteriorating heart failure and death. Therefore it is important for health care professionals caring for women in the peripartum period to be aware of the signs and symptoms of the diagnosis.
围产期心肌病的定义为心力衰竭，射血分数低于45%，发生于妊娠晚期或产后前五个月。尽管该病于1849年由里奇首次描述，但其背后的机制仍未完全明确。然而，孕期的氧化应激以及催乳素裂解为其16 kDa片段似乎在围产期心肌病的病理生理学中发挥作用。除了心力衰竭的最佳治疗外，还应考虑使用溴隐亭，一种催乳素释放抑制剂。患病率和预后因地域而异。大多数情况下，左心室射血分数在六个月后恢复正常，但有时该病会伴有心力衰竭恶化和死亡。因此，对于在围产期护理女性的医护人员而言，了解该诊断的体征和症状非常重要。
