Shetty Sindhu, Sharma Nidhi, Booth Christine N, Oshilaja Olaronke, Downs-Kelly Erinn P, McKenney Jesse K, Sturgis Charles D
Cleveland Clinic, Cleveland, OH, USA.
Mayo Clinic, Rochester, MN, USA.
Int J Surg Pathol. 2020 Aug;28(5):541-548. doi: 10.1177/1066896920901770. Epub 2020 Jan 28.
Rosai-Dorfman disease is a rare proliferative histiocytic disorder of lymph nodes that is descriptively known as sinus histiocytosis with massive lymphadenopathy. Extranodal involvement of the parenchyma of the breast is uncommonly reported, with fewer than 50 cases of mammary extranodal disease detailed in the English-language literature. We characterize a retrospective series of adult female patients from a single institution with Rosai-Dorfman disease of the breast and axillary lymph nodes. Because Rosai-Dorfman disease of the breast and axillary lymph nodes may clinically, radiographically, and histologically mimic breast carcinoma and other conditions, we present an illustrated review of the disease and its relevant differential diagnoses in hopes of raising awareness and allowing for accurate management of affected patients.
罗萨伊-多夫曼病是一种罕见的淋巴结增生性组织细胞疾病，其特征性表现为伴有巨大淋巴结病的窦组织细胞增生。乳腺实质的结外受累情况鲜有报道，英文文献中详细描述的乳腺结外疾病病例不足50例。我们对来自单一机构的一系列成年女性乳腺及腋窝淋巴结罗萨伊-多夫曼病患者进行了回顾性分析。由于乳腺及腋窝淋巴结罗萨伊-多夫曼病在临床、影像学和组织学上可能与乳腺癌及其他疾病相似，我们对该疾病及其相关鉴别诊断进行了图文并茂的综述，以期提高认识并实现对患者的准确管理。
