Gkentzi Despoina, Tsintoni Asimina, Christopoulou Irini, Mamalis Ilias, Paliogianni Fotini, Assimakopoulos Stelios F, Marangos Markos, Dimitriou Gabriel
Department of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece.
Department of Microbiology, University General Hospital of Patras, Patras Medical School, Rio, Greece.
J Chemother. 2020 Apr;32(2):103-106. doi: 10.1080/1120009X.2020.1716478. Epub 2020 Jan 29.
has evolved as a major pathogen of outbreaks in the healthcare setting with increased morbidity and mortality. In neonates, treatment can be quite challenging due to the resistance profile of as well as limited data on pharmakokinetics and pharmakodynamics of antibiotics in this age group. We present an outbreak of eight cases of extensively-drug resistant (XDR) bacteremias successfully managed with the combination of colistin with high dose ampicillin/sulbactam.
已演变为医疗机构中爆发疫情的主要病原体，发病率和死亡率不断上升。在新生儿中，由于其耐药情况以及该年龄组抗生素药代动力学和药效学数据有限，治疗颇具挑战性。我们报告了8例广泛耐药（XDR）菌血症的疫情，通过联合使用黏菌素和高剂量氨苄西林/舒巴坦成功治愈。
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