Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada.
Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada.
J Chromatogr A. 2020 May 10;1618:460892. doi: 10.1016/j.chroma.2020.460892. Epub 2020 Jan 15.
We discuss how the efficiency of a chromatography device could be enhanced by incorporating a new feature which ensures flow uniformity. The overall flow of fluid within the device, which has a cuboid shape, could be visualized as a combination of two z patterns. The device is therefore designated as cuboid z. The reason for flow uniformity is explained using a simple mathematical model, and also based on computational fluid dynamic (CFD) simulations. The cuboid z device outperformed its equivalent conventional cylindrical column in terms of separation efficiency metrics such as the number of theoretical plates, the reduced plate height, and attributes of non-interacting tracer solute peaks. The results discussed in this paper clearly indicate the suitability of the cuboid z device for carrying out high-resolution chromatographic separations. The z flow enhancing feature would also be broadly applicable to any process which requires uniform flow in three-dimensional porous media. In addition to superior fluidic attributes, the cuboid z chromatography device has other advantages such as compactness and scalability.
我们讨论了如何通过引入新的特征来提高色谱设备的效率，该特征可以确保流动的均匀性。设备的整体流动形状为长方体，可以视为两个 z 图案的组合。因此，该设备被指定为长方体 z。使用简单的数学模型和计算流体动力学 (CFD) 模拟来解释流动均匀性的原因。在分离效率指标方面，例如理论塔板数、板高降低和非相互作用示踪溶质峰的特性，长方体 z 设备优于等效的传统圆柱形柱。本文讨论的结果清楚地表明，长方体 z 设备适合进行高分辨率的色谱分离。z 流增强特征也将广泛适用于任何需要在三维多孔介质中均匀流动的过程。除了优越的流体特性外，长方体 z 色谱设备还有其他优点，例如紧凑性和可扩展性。
