Ya Luo, Jie Yu, Mengxue Yang, Pan Wang, Changwei Yang, Jie Xu
School of Public Health, Zunyi Medical University, Zunyi, Guizhou, P.R. China.
Department of Endocrinology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, P.R. China.
Iran J Public Health. 2019 Dec;48(12):2210-2215.
To identify serum nonylphenol (NP) and glucolipid metabolism-related proteins in Type 2 diabetes (T2D) patients.
We performed a hospital-based, case-control study in patients admitted to the Department of Endocrinology, Hospital of Zunyi Medical University, Zunyi City, China from Mar to Nov of 2014. The study included 112 T2D cases diagnosed in accordance with the 2013 WHO Expert Committee Diabetes Diagnosing Criteria, and 125 healthy individuals with normal fasting blood glucose (FBG) when receiving physical examination in the same period in the Municipal Physical Examination Center. Blood samples from subjects in the 2 groups underwent detection of biochemical indices, including FBG, blood fat, and NP. Glucolipid metabolism-related proteins, including estrogen receptor (ER), sterol regulatory element-binding protein-1c (SREBP-1c), wingless-type MMTV integration site family member 5a (Wnt5a), and peroxisome proliferator-activated receptor-γ (PPAR-γ). These indices were compared between the 2 groups to analyze the correlation between serum NP levels and glucolipid metabolic proteins.
The subjects in the diabetes group had higher triglycerides (TG), total cholesterol (TC), NP, ER, SREBP-1c, Wnt5a, FBG, and TG levels than the healthy group, but lower levels of low-density lipoprotein cholesterol (LDL-C) and PPAR-γ than the healthy group. No significant differences in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were found between the two groups. The serum NP levels were shown to be positively correlated with SREBP-1c but negatively correlated with PPAR-γ.
The serum NP levels of T2D patients is higher than the levels in healthy controls, and its levels correlate with SREBP-1c and PPAR-γ levels.
鉴定2型糖尿病（T2D）患者血清中的壬基酚（NP）及糖脂代谢相关蛋白。
2014年3月至11月，我们在遵义医科大学附属医院内分泌科住院患者中开展了一项基于医院的病例对照研究。该研究纳入了112例根据2013年世界卫生组织专家委员会糖尿病诊断标准确诊的T2D患者，以及125例同期在市体检中心接受体检时空腹血糖（FBG）正常的健康个体。两组受试者的血样均进行了生化指标检测，包括FBG、血脂和NP。检测糖脂代谢相关蛋白，包括雌激素受体（ER）、固醇调节元件结合蛋白-1c（SREBP-1c）、无翅型MMTV整合位点家族成员5a（Wnt5a）和过氧化物酶体增殖物激活受体-γ（PPAR-γ）。比较两组间这些指标，以分析血清NP水平与糖脂代谢蛋白之间的相关性。
糖尿病组受试者的甘油三酯（TG）、总胆固醇（TC）、NP、ER、SREBP-1c、Wnt5a、FBG和TG水平高于健康组，但低密度脂蛋白胆固醇（LDL-C）和PPAR-γ水平低于健康组。两组间丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）无显著差异。血清NP水平与SREBP-1c呈正相关，但与PPAR-γ呈负相关。
T2D患者血清NP水平高于健康对照，且其水平与SREBP-1c和PPAR-γ水平相关。
