Department of Pathology, University of Chicago Medical Center, Chicago, IL.
Am J Clin Pathol. 2020 May 5;153(6):772-775. doi: 10.1093/ajcp/aqz211.
To determine how often end-stage kidney disease (ESKD) is implicated as a cause of death (COD) at autopsy.
We searched our autopsy database (2007-2017) using queries "end-stage renal disease," "end-stage kidney disease," "ESRD," "chronic renal disease," and "chronic kidney disease." Final diagnosis and summaries were reviewed to determine if ESKD was appropriately correlated with the COD. Cases in which the COD was unrelated to kidney function were excluded.
Eighty-five patients with a history of ESKD and histologic confirmation thereof were identified. Their CODs were cardiovascular (36%), infection/sepsis (41%), pulmonary (6%), gastrointestinal/hepatic (2%), central nervous system (3%), other systemic disease (7%), and unspecified (5%). ESKD was implicated as a contributing COD in 24 (28%) cases.
ESKD is often overlooked at autopsy, particularly in patients with cardiovascular or infectious disease. Accurate documentation of ESKD contributing to mortality is important for education, counseling, record maintenance, and directing research efforts.
确定在尸检中终末期肾病（ESKD）作为死因（COD）的出现频率。
我们使用“终末期肾病”、“终末期肾脏病”、“ESRD”、“慢性肾脏病”和“慢性肾病”等查询词在我们的尸检数据库（2007-2017 年）中进行搜索。查看最终诊断和摘要，以确定 ESKD 是否与 COD 有恰当关联。排除 COD 与肾功能无关的病例。
确定了 85 例有 ESKD 病史和组织学证实的患者。他们的 COD 为心血管疾病（36%）、感染/败血症（41%）、肺部（6%）、胃肠道/肝脏（2%）、中枢神经系统（3%）、其他全身性疾病（7%）和未特指原因（5%）。ESKD 被认为是 24 例（28%）COD 的促成因素。
ESKD 在尸检中经常被忽视，特别是在患有心血管疾病或传染病的患者中。准确记录 ESKD 对死亡率的影响对于教育、咨询、记录保存和指导研究工作很重要。
