Gilkeson G, Polisson R, Sinclair H, Vogler J, Rice J, Caldwell D, Spritzer C, Martinez S
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
J Rheumatol. 1988 Sep;15(9):1361-6.
A pilot study comparing standard radiography to magnetic resonance imaging (MRI) was performed on the wrists of 10 patients with early (anatomic Stage I or II) rheumatoid arthritis (RA). MRI was found to be superior to standard radiographs in 2 respects: (1) synovial inflammation was impressively demonstrated on T2 weighted images, whereas plain films merely suggested soft tissue swelling; and (2) T1 and T2 weighted images clearly revealed erosions of several carpal bones which were not noted on standard radiographs. Although the expense of MRI currently precludes its routine use in clinical practice, the apparent sensitivity of this diagnostic modality for detecting early changes in RA might make it an invaluable tool for therapeutic decision making or for assessing response in interventional trials.
对10例早期（解剖学分期I期或II期）类风湿性关节炎（RA）患者的手腕进行了一项将标准X线摄影与磁共振成像（MRI）相比较的初步研究。结果发现MRI在两个方面优于标准X线片：（1）在T2加权图像上滑膜炎症显示得很明显，而平片仅提示软组织肿胀；（2）T1和T2加权图像清楚地显示了几块腕骨的侵蚀，而标准X线片上未发现这些侵蚀。尽管目前MRI的费用使其无法在临床实践中常规使用，但这种诊断方法在检测RA早期变化方面的明显敏感性可能使其成为治疗决策或评估干预试验反应的宝贵工具。
