采用基于人群的癌症登记数据，利用 2003-2012 年在中国林州进行的灵活参数模型估计胃癌的相对生存率和治愈率。

The relative survival and cure fraction of gastric cancer estimated through flexible parametric models using data from population-based cancer registration during 2003-2012 in Linzhou, China.

机构信息

Department of Epidemiology, Affiliated Cancer Hospital of Zhengzhou University/ Henan Provincial Cancer Hospital, Zhengzhou, China.

Linzhou Cancer Registry, Linzhou Cancer Hospital, Linzhou, China.

出版信息

Cancer Med. 2020 Mar;9(6):2243-2251. doi: 10.1002/cam4.2831. Epub 2020 Jan 28.

DOI:10.1002/cam4.2831

PMID:31994324

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7064094/

Abstract

PURPOSE

The proportion of cured gastric cancer patients has drawn the attention of patients, physicians, and healthcare providers after comprehensive prevention and control measures were carried out for several years. Therefore, the relative survival and cure fraction were estimated in our study.

METHODS

Population-based cancer registration data were used to estimate survival and cure fraction. A total of 7585 gastric cancer cases (ICD10:C16.0 ~ C16.9) were extracted and included in the final analysis. Cases were diagnosed in 2003-2012 and followed until the end of 2017. Relative survival was calculated as the ratio between the observed survival through the life-table method. The expected survival was estimated by the Ederer II method. The cure fraction was estimated using flexible parametric cure models stratified by age and calendar period when the cases were diagnosed.

RESULTS

The 5-year relative survival of cardia gastric cancer increased with the calendar period of 2003-2004, 2005-2006, 2007-2008, 2009-2010, and 2011-2012 (27.5%, 28.3%, 33.5%, 38.2%, and 46.8%, respectively). The increasing trend along with the calendar periods was also observed in cure proportion of cardia gastric cancer (24.8%, 25.2%, 31.7%, 36.0%, and 43.1%, respectively). Notable improvement of cure proportion was observed in the period of 2011-2012, compared with the initial period of 2003-2004. There was an improvement of 79.8% among all gastric cancer subjects, and it was 74.1% and 55.7% in cardia gastric and noncardia gastric cancer subjects, respectively. The median survival of "uncured" patients showed no significant improvement along with the calendar periods in all age groups.

CONCLUSIONS

Notable improvement of gastric cancer relative survival and cure proportion was observed in Linzhou during 2003-2012.

摘要

目的

在实施了多年的综合防治措施后，治愈的胃癌患者比例引起了患者、医生和医疗保健提供者的关注。因此，本研究中估计了相对生存率和治愈率。

方法

利用基于人群的癌症登记数据来估计生存率和治愈率。共提取了 7585 例胃癌病例（ICD10：C16.0~C16.9）并纳入最终分析。病例诊断于 2003-2012 年，随访至 2017 年底。相对生存率通过生命表法计算观察生存率得出。预期生存率通过 Ederer II 法估计。治愈率通过按年龄和病例诊断时的日历期分层的灵活参数治愈模型进行估计。

结果

贲门胃癌的 5 年相对生存率随着 2003-2004 年、2005-2006 年、2007-2008 年、2009-2010 年和 2011-2012 年的日历期增加（分别为 27.5%、28.3%、33.5%、38.2%和 46.8%）。贲门胃癌的治愈率也呈现出随着日历期增加的趋势（分别为 24.8%、25.2%、31.7%、36.0%和 43.1%）。在 2011-2012 年期间，与 2003-2004 年初期相比，治愈率显著提高。所有胃癌患者的治愈率提高了 79.8%，贲门胃癌和非贲门胃癌患者的治愈率分别提高了 74.1%和 55.7%。所有年龄组的“未治愈”患者的中位生存时间未随着日历期的变化而显著改善。