Faria João Carlos Pina, Victorino Camila Augusta, Sato Monica Akemi
Faculdade de Medicina do ABC, Centro Universitário Saúde ABC, Santo André, SP, Brazil.
Universidade Nove de Julho, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2020 Jan 27;18:eRW5055. doi: 10.31744/einstein_journal/2020RW5055. eCollection 2020.
The objective of the present study was to assess the efficacy of different doses, times for infusion of the first dose, intervals of administration of subsequent doses, and number of epinephrine doses in the survival of children and adolescents who went into cardiorespiratory arrest. It is a review study with data from the PubMedⓇ/MEDLINEⓇdatabase. The search was for articles published from January 1st, 2000 to February 10, 2019, with a sample of patients aged under 18 years, published in English, Portuguese and Spanish. We found 222 articles, of which 16 met the inclusion criteria of the study. The first dose should be given as soon as possible. The standard dose (0.01mg/kg) has a better outcome when compared to the higher dose (0.1mg/kg). There is an iⓇverse relation between the number of epinephrine doses and survival. The interval currently recommended between doses has lower survival when compared to larger intervals. The dosage recommended by the American Heart Association presents a better outcome for survival, but the interval between doses and the maximum number of doses should be better assessed.
本研究的目的是评估不同剂量、首次给药输注时间、后续给药间隔以及肾上腺素给药次数对发生心肺骤停的儿童和青少年生存情况的影响。这是一项基于PubMedⓇ/MEDLINEⓇ数据库数据的综述研究。检索的是2000年1月1日至2019年2月10日发表的文章，研究样本为18岁以下患者，文章语言为英语、葡萄牙语和西班牙语。我们共找到222篇文章，其中16篇符合该研究的纳入标准。首剂应尽快给予。与高剂量（0.1mg/kg）相比，标准剂量（0.01mg/kg）的效果更好。肾上腺素给药次数与生存率呈负相关。与较长间隔相比，目前推荐的给药间隔生存率较低。美国心脏协会推荐的剂量生存率更佳，但给药间隔和最大给药次数仍需进一步评估。
