子宫平滑肌瘤与健康子宫肌层中KI-67表达的评估：一项试点研究。

Evaluation of KI-67 expression in uterine leiomyoma and in healthy myometrium: a pilot study.

作者信息

Eulálio Filho Walberto Monteiro Neiva, Soares Eduardo Augusto Sousa, Lima Maria Simone Oliveira, Brazil Emerson Davi do Nascimento, Rodrigues Rodolfo Myronn de Melo, Zeron Rubens Moura Campos, Silva Benedito Borges, Costa Pedro Vitor Lopes

机构信息

. Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Piauí, Teresina, PI, Brasil.

. Universidade Federal do Piauí, Departamento de Ginecologia, Teresina, PI, Brasil.

出版信息

Rev Assoc Med Bras (1992). 2019 Dec;65(12):1459-1463. doi: 10.1590/1806-9282.65.12.1459.

DOI:10.1590/1806-9282.65.12.1459

PMID:31994626

Abstract

OBJECTIVE

Evaluate the expression of KI-67 in uterine leiomyomas and adjacent myometrial tissue and verify the existence of a correlation between clinical parameters and KI-67 expression in tumors.

METHODS

This is a cross-sectional, controlled, analytical study. Samples of leiomyomas and myometrium were obtained from patients who underwent hysterectomy. The samples were processed by immunohistochemistry using KI-67 antibody, and the expression was evaluated by two blinded observers. Student›s T-test was used for comparison of means, and Pearson›s P test for correlation with clinical parameters.

RESULTS

A total of 9 patients were included in the study. The mean age was 40.7 years, ranging from 35 to 44 years. The mean expression of KI-67 in myometrium was 1.63%, and, in leiomyomas, 5.96% (p <0.001). The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level.

CONCLUSION

The expression of KI-67 in normal myometrium was significantly lower than in leiomyomas. The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level in the patients of this study.

摘要