Eslamian Ladan, Torshabi Maryam, Motamedian Saeed Reza, Hemmati Yasamin Babaee, Mortazavi Seyed Alireza
Shahid Beheshti University of Medical Sciences, Dentofacial Deformities Research Center, Department of Orthodontics, School of Dentistry (Tehran, Iran).
Shahid Beheshti University of Medical Sciences, Dental Biomaterials Department, School of Dentistry (Tehran, Iran).
Dental Press J Orthod. 2019 Nov-Dec;24(6):27e1-27e7. doi: 10.1590/2177-6709.24.6.27.e1-7.onl.
Pain related to orthodontic tooth movement is common and cause dissatisfaction and discomfort. Objective: The present study aimed to compare the efficacy of naproxen patches in pain control during orthodontic tooth separation, by means of visual analogue scale (VAS) and interleukin 1β (IL-1β) levels in gingival crevicular fluid (GCF).
In this split-mouth triple-blind clinical trial, with 40 patients following separation, 5% naproxen or placebo patches were randomly placed on the upper right or left first molars every 8 hours. Pain intensity scores were determined after 2 and 6 hours, sleep time, 24 hours, days 2, 3 and 7 by the patients using a 100-mm VAS ruler. IL-1β levels in GCF were evaluated by ELISA at baseline, 1 and 24 hours and 7 days. Paired samples t-tests and two-way repeated measures ANOVA analysis of variance with a significance level of 0.05 were applied.
A total number of 30 patients (13 males and 17 females) finished the trial. Significant differences were found in pain scores (p< 0.0001) and IL-1β levels (p= 0.047) between naproxen and placebo groups. Lower pain scores were reported for the patients using naproxen patches at all time points, except 1 hour after separation. IL-1β levels were lower for the patients using naproxen patches only 1 hour after separation (p= 0.047). The peak of pain scores and IL-1β levels were calculated at 24 hours.
In the light of VAS scores and IL-1β levels, naproxen patches reduced the pain caused by separator placement.
与正畸牙齿移动相关的疼痛很常见，会导致患者不满和不适。目的：本研究旨在通过视觉模拟量表（VAS）和龈沟液（GCF）中白细胞介素1β（IL-1β）水平，比较萘普生贴片在正畸牙齿分离过程中控制疼痛的疗效。
在这项双盲临床试验中，40例接受牙齿分离的患者，每8小时在右上或左上第一磨牙上随机贴敷5%萘普生或安慰剂贴片。患者在分离后2小时、6小时、睡眠时间、24小时、第2天、第3天和第7天使用100毫米VAS尺确定疼痛强度评分。在基线、1小时、24小时和7天时通过酶联免疫吸附测定（ELISA）评估GCF中的IL-1β水平。应用配对样本t检验和显著性水平为0.05的双向重复测量方差分析。
共有30例患者（13例男性和17例女性）完成试验。萘普生组和安慰剂组在疼痛评分（p<0.0001）和IL-1β水平（p=0.047）上存在显著差异。除分离后1小时外，使用萘普生贴片的患者在所有时间点的疼痛评分均较低。仅在分离后1小时，使用萘普生贴片的患者IL-1β水平较低（p=0.047）。疼痛评分和IL-1β水平的峰值在24小时时计算得出。
根据VAS评分和IL-1β水平，萘普生贴片减轻了分离器放置引起的疼痛。
