Eslamian Ladan, Borzabadi-Farahani Ali, Gholami Hadi
Aust Orthod J. 2016 May;32(1):64-72.
To compare the analgesic effect of topical benzocaine (5%) and ketoprofen (1.60 mg/mL) after 2 mm activation of 7 mm long delta loops used for maxillary en-masse orthodontic space closure.
Twenty patients (seven males, 13 females, 15-25 years of age, mean age of 19.5 years) participated in a randomised crossover, double-blind trial. After appliance activation, participants were instructed to use analgesic gels and record pain perception at 2, 6, 24 hours and 2, 3 and 7 days (at 18.00 hrs), using a visual analogue scale ruler (VAS, 0-4). Each patient received all three gels (benzocaine, ketoprofen, and a control (placebo)) randomly, but at three different appliance activation visits following a wash-over gap of one month. After the first day, the patients were instructed to repeat gel application twice a day at 10:00 and 18:00 hrs for three days. The recorded pain scores were subjected to non-parametric analysis.
The highest pain was recorded at 2 and 6 hours. Pain scores were significantly different between the three groups (Kruskal-Wallis test, p < 0.01). The overall mean (SD) pain scores for the benzocaine 5%, ketoprofen, and control (placebo) groups were 0.89 (0.41), 0.68 (0.34), and 1.15 (0.81), respectively. The pain scores were significantly different between the ketoprofen and control groups (mean difference = 0.47, p = 0.005). All groups demonstrated significant differences in pain scores at the six different time intervals (p < 0.05) and there was no gender difference (p > 0.05).
A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo). The highest pain scores were experienced in patients administered the placebo and the lowest scores in patients who applied ketoprofen gel. Benzocaine had an effect mid-way between ketoprofen and the placebo. The highest pain scores were recorded 2 hours following force application, which decreased to the lowest scores after 7 days.
比较在用于上颌整体正畸间隙关闭的7毫米长δ形曲激活2毫米后，外用苯佐卡因（5%）和酮洛芬（1.60毫克/毫升）的镇痛效果。
20名患者（7名男性，13名女性，年龄15 - 25岁，平均年龄19.5岁）参与了一项随机交叉双盲试验。矫治器激活后，指导参与者使用镇痛凝胶，并使用视觉模拟量表尺（VAS，0 - 4）记录在2、6、24小时以及2、3和7天（18:00时）的疼痛感受。每位患者随机接受所有三种凝胶（苯佐卡因、酮洛芬和一种对照（安慰剂）），但在间隔一个月的三次不同矫治器激活就诊时接受。第一天后，指导患者在接下来的三天每天10:00和18:00重复涂抹凝胶两次。对记录的疼痛评分进行非参数分析。
在2小时和6小时记录到的疼痛程度最高。三组之间的疼痛评分有显著差异（Kruskal - Wallis检验，p < 0.01）。5%苯佐卡因、酮洛芬和对照组（安慰剂）的总体平均（标准差）疼痛评分分别为0.89（0.41）、0.68（0.34）和1.15（0.81）。酮洛芬组和对照组之间的疼痛评分有显著差异（平均差值 = 0.47，p = 0.005）。所有组在六个不同时间间隔的疼痛评分均有显著差异（p < 0.05），且不存在性别差异（p > 0.05）。
与对照凝胶（安慰剂）相比，使用酮洛芬后观察到疼痛显著减轻。接受安慰剂的患者疼痛评分最高，应用酮洛芬凝胶的患者评分最低。苯佐卡因的效果介于酮洛芬和安慰剂之间。施加力后2小时记录到最高疼痛评分，7天后降至最低评分。
