T Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Int J Cancer. 2020 Jul 15;147(2):307-316. doi: 10.1002/ijc.32888. Epub 2020 Feb 25.
In noncancerous tissues, neighboring cells coexist in metabolic harmony. This metabolic harmony is disrupted in cancerous tissues, often accompanied by genetic mutations. Tumor cells fundamentally change the metabolite profiles in the tumor microenvironment to favor their own growth. In this review, we will discuss several examples in which genetic mutations reprogram tumor cell metabolic pathways, leading to the consumption of essential nutrients in the tumor microenvironment, production of toxic byproducts, and suppression of antitumor immune cell metabolic fitness and tumor-killing function. Finally, we will briefly discuss how immune checkpoint blockade overcomes the metabolic suppression of tumor-infiltrating immune cells.
在非癌组织中，相邻细胞共存于代谢协调中。这种代谢协调在癌组织中被破坏，通常伴随着基因突变。肿瘤细胞从根本上改变肿瘤微环境中的代谢物谱，以促进自身生长。在这篇综述中，我们将讨论几种遗传突变重新编程肿瘤细胞代谢途径的例子，导致肿瘤微环境中必需营养素的消耗、有毒副产物的产生以及抗肿瘤免疫细胞代谢适应性和杀伤功能的抑制。最后，我们将简要讨论免疫检查点阻断如何克服肿瘤浸润免疫细胞的代谢抑制。
