Shibamoto Y, Sasai K, Takahashi M, Abe M
Dept. of Radiology, Faculty of Med. Kyoto Univ.
Gan No Rinsho. 1988 Oct;34(13):1859-63.
Recent developments in the evaluation methods for hypoxic cell sensitizers were reported with emphasis on the following 3 points. (1) A new sensitizer-screening system consisting of the EMT 6 single cell, spheroid, and solid tumor was proposed by us and was found to be a useful, sophisticated system. (2) In the in vivo experiments, irradiation conditions for mice and the drug dose level influenced the hypoxic fraction of tumors significantly. Investigators must always take these facts into consideration when doing in vivo experiments. (3) Three new compounds recently developed in Japan proved to be superior to misonidazole.
本文报道了低氧细胞增敏剂评估方法的最新进展，重点如下三点：（1）我们提出了一种由EMT 6单细胞、球体和实体瘤组成的新型增敏剂筛选系统，该系统被证明是一个有用且复杂的系统。（2）在体内实验中，小鼠的照射条件和药物剂量水平对肿瘤的低氧分数有显著影响。研究人员在进行体内实验时必须始终考虑这些因素。（3）日本最近研发的三种新化合物被证明优于米索硝唑。
