肿瘤大小对米索硝唑放射增敏作用的影响。
Influence of tumour size on radiosensitization by misonidazole.
作者信息
Stanley J A, Peckham M J, Steel G G
出版信息
Br J Cancer Suppl. 1978 Jun;3:220-4.
The administration of misonidazole shortly before irradiation increased the radiation response of the Lewis lung tumour growing either as approximately 500mm3 subcutaneous implants or as 15mm3 lung colonies. In the subcutaneous tumours, the dose enhancement ratio was approximately half the oxygen enhancement ratio. In the lung colonies the sensitization of hypoxic cells appeared to be complete. Similar studies on subcutaneous B16 melanoma showed that the drug increased radiosensitivity to a level comparable with that of cells in small pulmonary nodules, whose hypoxic fraction appears to be below 10(-3). The results indicate complete dose modification of hypoxic cells where their natural proportion is small with incomplete enhancement of radiosensitivity where the natural hypoxic fraction is larger.
在照射前不久给予米索硝唑，可增强Lewis肺癌的辐射反应，该肿瘤以约500mm³皮下植入物或15mm³肺集落的形式生长。在皮下肿瘤中，剂量增强比约为氧增强比的一半。在肺集落中，缺氧细胞的致敏作用似乎是完全的。对皮下B16黑色素瘤的类似研究表明，该药物将放射敏感性提高到与小肺结节中的细胞相当的水平，小肺结节中缺氧部分似乎低于10⁻³。结果表明，在缺氧细胞自然比例较小的情况下，其剂量可完全改变，而在自然缺氧比例较大的情况下，放射敏感性增强不完全。
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