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氦束射线照相术的空间分辨率改善技术。

A technique for spatial resolution improvement in helium-beam radiography.

机构信息

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.

出版信息

Med Phys. 2020 Jun;47(5):2212-2221. doi: 10.1002/mp.14051. Epub 2020 Mar 10.

Abstract

PURPOSE

Ion-beam radiography exhibits a significantly lower spatial resolution (SR) compared to x-ray radiography. This is mostly due the multiple Coulomb scattering (MCS) that the ions undergo in the imaged object. In this work, a novel technique to improve the spatial resolution in helium-beam radiography was developed. Increasing helium-beam energies were exploited in order to decrease the MCS, and therefore increase the SR.

METHODS

The experimental investigation was carried out with a dedicated ion-tracking imaging system fully composed of thin, pixelated silicon detectors (Timepix). Four helium beams with increasing energies (from 168.8 to 220.5 MeV/u) were used to image a homogeneous 160 mm PMMA phantom with a 2 mm air gap at middle depth. An energy degrader (ED) was placed between the rear tracking system and the energy-deposition detector to compensate for the longer range associated with more energetic ions. The SR was measured for each beam energy. To take into account the overall impact on the image quality, the contrast-to-noise ratio (CNR), the single-ion water equivalent thickness (WET) precision and the absorbed dose in the phantom were also evaluated as a function of the initial beam energy. FLUKA Monte Carlo simulations were used to support the conceptual design of the experimental setup and for dose estimation.

RESULTS

In the investigated energy interval, a total SR increase by around 30% was measured with increasing beam energy, reaching a maximum value of 0.69 lp/mm. For radiographs generated with 350 μGy of absorbed dose and 220 μm pixel size, a CNR decrease of 32% was found as the beam energy increases. For 1 mm pixel size, the CNR decreases only by 22%. The CNR of the images was always above 6. The single-ion WET precision was found to be in a range between 1.2% and 1.5%.

CONCLUSIONS

We have experimentally shown and quantified the possibility of improving SR in helium-beam radiography by using increasing beam energies in combination with an ED. A significant SR increase was measured with an acceptable decrease of CNR. Furthermore, we have shown that an ED can be a valuable tool to exploit increasing beam energies to generate energy-deposition radiographs.

摘要

目的

与 X 射线射线照相相比,离子束射线照相的空间分辨率(SR)明显较低。这主要是由于离子在被成像物体中经历的多次库仑散射(MCS)。在这项工作中,开发了一种提高氦束射线照相空间分辨率的新技术。为了减少 MCS,从而提高 SR,利用了增加的氦束能量。

方法

使用完全由薄的、像素化的硅探测器(Timepix)组成的专用离子跟踪成像系统进行实验研究。使用四束能量逐渐增加的氦束(从 168.8 到 220.5 MeV/u)来对具有 2 毫米空气间隙的中间深度的均匀 160 毫米 PMMA 体模进行成像。在后部跟踪系统和能量沉积探测器之间放置了一个能量衰减器(ED),以补偿与高能离子相关的更长射程。测量了每个光束能量的 SR。为了考虑对图像质量的整体影响,还评估了对比度噪声比(CNR)、单离子水等效厚度(WET)精度和体模中的吸收剂量,作为初始光束能量的函数。FLUKA 蒙特卡罗模拟用于支持实验装置的概念设计和剂量估算。

结果

在所研究的能量范围内,随着光束能量的增加,SR 总共增加了约 30%,达到了 0.69 lp/mm 的最大值。对于用 350 μGy 的吸收剂量和 220 μm 的像素尺寸生成的射线照片,随着光束能量的增加,发现 CNR 下降了 32%。对于 1mm 的像素尺寸,CNR 仅下降 22%。图像的 CNR 始终高于 6。单离子 WET 精度在 1.2%到 1.5%之间。

结论

我们通过使用增加的光束能量结合 ED,在实验中证明并量化了提高氦束射线照相 SR 的可能性。测量到 SR 显著增加,同时 CNR 适度降低。此外,我们已经表明,ED 可以成为利用增加的光束能量生成能量沉积射线照片的有价值的工具。

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