用肝毒素处理的大鼠血浆中胺氧化酶的变化。

Changes in amine oxidase in plasma of rats treated with hepatotoxins.

作者信息

Obata T, Egashira T, Yamanaka Y

机构信息

Department of Pharmacology, Medical College of Oita, Japan.

出版信息

Jpn J Pharmacol. 1988 Sep;48(1):142-4. doi: 10.1254/jjp.48.142.

DOI:10.1254/jjp.48.142

PMID:3199602

Abstract

When allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with beta-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl4), A-form MAO activity elevated predominantly. The deaminations of 5-HT and beta-PEA in these plasma treated with AF or CCl4 were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate that there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl4 or AF.

摘要

当将甲酸烯丙酯（AF）给予大鼠时，以β-苯乙胺为底物，发现血浆中B型单胺氧化酶（MAO）活性显著升高。相比之下，在四氯化碳（CCl4）的情况下，主要是A型MAO活性升高。用AF或CCl4处理的这些血浆中5-羟色胺（5-HT）和β-苯乙胺的脱氨基作用并未被高浓度的MAO抑制剂司来吉兰或氯吉兰完全抑制。这些结果表明，可能有两种或更多种不同的胺氧化酶从肝脏和其他器官释放出来，以响应CCl4或AF。