From the Department of Medicine (G.H.B., K.T.W.S.), University Hospitals Cleveland Medical Center, OH.
Case Western Reserve University School of Medicine, Cleveland, OH (G.H.B., K.T.W.S.).
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):541-553. doi: 10.1161/ATVBAHA.119.312142. Epub 2020 Jan 30.
Peripheral artery disease is an atherosclerotic disease of the lower extremities associated with high cardiovascular mortality. Management of this condition may include lifestyle modifications, medical management, endovascular repair, or surgery. The medical approach to peripheral artery disease is multifaceted and includes cholesterol reduction, antiplatelet therapy, anticoagulation, peripheral vasodilators, blood pressure management, exercise therapy, and smoking cessation. Adherence to this regimen can reduce limb-related complications like critical limb ischemia and amputation, as well as systemic complications of atherosclerosis like stroke and myocardial infarction. Relative to coronary artery disease, peripheral artery disease is an undertreated condition. In this article, we explore the evidence behind medical therapies for the management of peripheral artery disease.
外周动脉疾病是一种与心血管死亡率高相关的下肢动脉粥样硬化性疾病。这种疾病的治疗可能包括生活方式的改变、药物治疗、血管内修复或手术。外周动脉疾病的医学治疗方法是多方面的，包括降低胆固醇、抗血小板治疗、抗凝、外周血管扩张剂、血压管理、运动治疗和戒烟。坚持这种治疗方案可以减少与肢体相关的并发症，如严重肢体缺血和截肢，以及动脉粥样硬化的全身性并发症，如中风和心肌梗死。与冠状动脉疾病相比，外周动脉疾病的治疗不足。在本文中，我们探讨了外周动脉疾病管理的药物治疗的证据。
