Loureiro-Ga Marcos, Veiga Cesar, Fdez-Manin Generosa, Jimenez Victor Alfonso, Calvo-Iglesias Francisco, Iñiguez Andres
Applied Mathematics Department II - Telecommunications Engineering Faculty, Univeristiy of Vigo, Vigo, Spain.
Cardiology Department, Galicia Sur Health Research Institute (IIS Galicia Sur). SERGAS-UVIGO, Vigo, Spain.
Comput Methods Biomech Biomed Engin. 2020 Jun;23(8):303-311. doi: 10.1080/10255842.2020.1720001. Epub 2020 Jan 29.
Aortic stenosis (AS) disease is a narrowing of the aortic valve (AV) opening which reduces blood flow from the heart causing several health complications. Although a lot of work has been done in AV simulations, most of the efforts have been conducted regarding healthy valves. In this article, a new three-dimensional patient-specific biomechanical model of the valve, based on a parametric formulation of the stenosis that permits the simulation of different degrees of pathology, is presented. The formulation is based on a double approach: the first one is done from the geometric point of view, reducing the effective ejection area of the AV by joining leaflets using a zipper effect to sew them; the second one, in terms of functionality, is based on the modification of AV tissue properties due to the effect of calcifications. Both healthy and stenotic valves were created using patient-specific data and results of the numerical simulation of the valve function are provided. Analysis of the results shows a variation in the first principal stress, geometric orifice area, and blood velocity which were validated against clinical data. Thus, the possibility to create a pipeline which allows the integration of patient-specific data from echocardiographic images and iFR studies to perform finite elements analysis is proved.
主动脉瓣狭窄（AS）疾病是指主动脉瓣（AV）开口变窄，从而减少心脏的血流，引发多种健康并发症。尽管在主动脉瓣模拟方面已经开展了大量工作，但大多数研究都集中在健康瓣膜上。本文提出了一种新的针对患者的瓣膜三维生物力学模型，该模型基于狭窄的参数化公式，能够模拟不同程度的病变情况。该公式基于双重方法：第一种方法是从几何角度出发，利用拉链效应将瓣叶连接起来，以减少主动脉瓣的有效射血面积；第二种方法是从功能角度出发，基于钙化对主动脉瓣组织特性的影响进行修正。利用患者的特定数据创建了健康瓣膜和狭窄瓣膜，并给出了瓣膜功能数值模拟的结果。结果分析表明，第一主应力、几何开口面积和血流速度存在变化，并与临床数据进行了验证。因此，证明了创建一个管道的可能性，该管道允许整合来自超声心动图图像和iFR研究的患者特定数据，以进行有限元分析。
