[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion].

Coronary arterial occlusion, maintained for 7 days in rabbits was accompanied by a marked and fairly stable drop in macroergic phosphates (ATP, creatine phosphate), seen in the perinecrotic and distant left and right ventricular myocardium. The administration of 0.5 mg/kg propranolol twice daily within 30-40 min after coronary arterial ligation resulted in a significant increase in ATP and the adenine nucleotides pool at a distance from the necrotic focus in the right and left ventricular myocardium on treatment days 3 and 7 and did not affect the recovery of normal creatine phosphate in the same myocardial areas. Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals.