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2017年韩国济州岛伤寒热暴发起源的系统发育分析

Phylogenetic Analysis for the Origin of Typhoid Fever Outbreak on Jeju Island, Korea, in 2017.

作者信息

Lee Keun Hwa, Yoo Jeong Rae, Kim Young Ree, Heo Sang Taek

机构信息

Department of Microbiology and Immunology, Hanyang University College of Medicine, Seoul, Korea.

Division of Infectious Disease, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.

出版信息

Infect Chemother. 2020 Sep;52(3):421-426. doi: 10.3947/ic.2020.52.3.421. Epub 2020 Mar 17.

DOI:10.3947/ic.2020.52.3.421
PMID:31997603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7533213/
Abstract

In June 2017, on Jeju Island, six patients were diagnosed with typhoid fever. All six patients were admitted to our hospital with fever, all of them had been working at the same hotel. The and genes of four out of six cases were amplified by polymerase chain reaction. The phylogenetic tree of the genes showed that the isolates from Jeju Island in 2017 had the same genotype and were similar to isolates from the United Kingdom. The origin of the isolates of the outbreak was the same, and the disease strain may have been imported from outside of Korea.

摘要

2017年6月，在济州岛，6名患者被诊断为伤寒。所有6名患者均因发热入院，他们都在同一家酒店工作。通过聚合酶链反应扩增了6例病例中4例的 和 基因。基因系统发育树显示，2017年济州岛分离株具有相同的基因型，且与英国分离株相似。此次疫情分离株来源相同，致病菌株可能是从韩国境外输入的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4878/7533213/9e72b60da49c/ic-52-421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4878/7533213/ef8a6e29f070/ic-52-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4878/7533213/9e72b60da49c/ic-52-421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4878/7533213/ef8a6e29f070/ic-52-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4878/7533213/9e72b60da49c/ic-52-421-g002.jpg

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本文引用的文献

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Patterns of rpoC Mutations in Drug-Resistant Mycobacterium tuberculosis Isolated from Patients in South Korea.从韩国患者中分离出的耐多药结核分枝杆菌中rpoC基因突变模式
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