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The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?

作者信息

Chau Dennis Dik-Long, Lau Kwok-Fai

机构信息

School of Life Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

出版信息

Neural Regen Res. 2020 Aug;15(8):1475-1476. doi: 10.4103/1673-5374.274334.

DOI:10.4103/1673-5374.274334
PMID:31997808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7059589/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d2d/7059589/54535d4d7bb2/NRR-15-1475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d2d/7059589/1638abd66521/NRR-15-1475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d2d/7059589/54535d4d7bb2/NRR-15-1475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d2d/7059589/1638abd66521/NRR-15-1475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d2d/7059589/54535d4d7bb2/NRR-15-1475-g002.jpg

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The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?非典型蛋白激酶C（aPKCs）在神经系统中的作用：神经再生的靶点？
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本文引用的文献

1
Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.非典型蛋白激酶 C 介导的吞噬衔接蛋白含有 PTB 结构域 1 第 35 位苏氨酸磷酸化对淀粉样β生成的抑制作用。
FASEB J. 2019 Nov;33(11):12019-12035. doi: 10.1096/fj.201802825RR. Epub 2019 Aug 5.
2
Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease.二甲双胍改善阿尔茨海默病 SAMP8 小鼠模型的学习和记忆能力。
J Alzheimers Dis. 2019;68(4):1699-1710. doi: 10.3233/JAD-181240.
3
Efficacy of Intranasal Insulin in Improving Cognition in Mild Cognitive Impairment and Alzheimer Disease: A Systematic Review and Meta-analysis.
鼻内胰岛素改善轻度认知障碍和阿尔茨海默病认知功能的疗效：一项系统评价和荟萃分析。
Am J Ther. 2019 Nov/Dec;26(6):e756-e762. doi: 10.1097/MJT.0000000000000926.
4
Altered expression of atypical PKC and Ryk in the spinal cord of a mouse model of amyotrophic lateral sclerosis.肌萎缩侧索硬化症小鼠模型脊髓中非典型蛋白激酶C和Ryk的表达改变
Dev Neurobiol. 2014 Aug;74(8):839-50. doi: 10.1002/dneu.22137. Epub 2014 Jan 22.
5
Competing molecular interactions of aPKC isoforms regulate neuronal polarity.PKC 同工型的竞争分子相互作用调节神经元极性。
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14450-5. doi: 10.1073/pnas.1301588110. Epub 2013 Aug 12.
6
PKM and the maintenance of memory.丙酮酸激酶M亚型与记忆维持
F1000 Biol Rep. 2013;5:4. doi: 10.3410/B5-4. Epub 2013 Feb 1.
7
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2.非典型蛋白激酶 Cι 对于 Wnt3a 依赖性的神经突生长是必需的，并且与磷酸化的 Dvl2 结合。
J Biol Chem. 2013 Mar 29;288(13):9438-46. doi: 10.1074/jbc.M112.448282. Epub 2013 Feb 8.
8
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.二甲双胍激活非典型蛋白激酶 C-CBP 通路，促进神经发生，增强空间记忆形成。
Cell Stem Cell. 2012 Jul 6;11(1):23-35. doi: 10.1016/j.stem.2012.03.016.
9
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.aPKC-Aurora A-NDEL1信号通路通过调节微管动力学在神经突伸长中起重要作用。
Nat Cell Biol. 2009 Sep;11(9):1057-68. doi: 10.1038/ncb1919. Epub 2009 Aug 9.
10
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.神经退行性疾病中的非典型蛋白激酶C II：tau蛋白病和α-突触核蛋白病中的PKCiota/lambda
J Neuropathol Exp Neurol. 2006 Apr;65(4):327-35. doi: 10.1097/01.jnen.0000218441.00040.82.