O'Sullivan Conor, Weible Aldis P, Wehr Michael
Institute of Neuroscience, University of Oregon, Eugene, OR, United States.
Department of Biology, University of Oregon, Eugene, OR, United States.
Front Neurosci. 2020 Jan 10;13:1394. doi: 10.3389/fnins.2019.01394. eCollection 2019.
Speech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and processing of speech sounds. Here we compared the relative importance of early and late speech-evoked activity for consonant discrimination. We trained mice to discriminate the initial consonants in spoken words, and then tested the effect of optogenetically suppressing different temporal windows of speech-evoked activity in auditory cortex. We found that both early and late suppression disrupted performance equivalently. These results suggest that mice are impaired at recognizing either type of disrupted representation because it differs from those learned in training.
言语会在听觉皮层引发强烈活动，该皮层包含广泛时空尺度上的信息。目前尚不清楚这些神经表征的哪些成分在语音的感知和处理中存在因果关联。在此，我们比较了早期和晚期言语诱发活动对辅音辨别能力的相对重要性。我们训练小鼠辨别口语单词中的初始辅音，然后测试光遗传学抑制听觉皮层中不同时间窗的言语诱发活动所产生的影响。我们发现早期和晚期抑制对表现的干扰程度相当。这些结果表明，小鼠在识别任何一种被扰乱的表征时都会受损，因为它与训练中所学的表征不同。
