Anastasya Karina Shasri, Iskandar Shelly, Atik Nur
Graduate School of Biomedical Sciences Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Department of Psychiatry, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia.
Evid Based Complement Alternat Med. 2020 Jan 7;2020:4658514. doi: 10.1155/2020/4658514. eCollection 2020.
Depression is one of the major problems, and the prevalence is higher among the elderly. The underlying mechanism of depression among this set of the population is multifactorial, and one of the most important factors in the pathophysiology of depression is the level of brain serotonin. Protein deficiency is linked to tryptophan deficiency that is known to be the essential material for the synthesis of serotonin. This randomized controlled trial looked for the effectiveness of eel's head powder administration on plasma tryptophan level and geriatric depression scale (GDS) scores among the elderly population who suffered from depression. The subjects were divided into three intervention groups, including groups that were given 2-week course of 5 mg/kg BW eel's head powder, 10 mg/kg BW eel's head powder, and placebo, respectively. There was a significant difference in plasma tryptophan level and geriatric depression scale between the 10 mg/kg BW group and 5 mg/kg BW group. There was also a significant difference between those given 10 mg/kg BW eel's head powder and those receiving placebo; however, no such difference was found between those in the 5 mg/kg BW eel's head powder group and placebo group. Eel's head powder administration could increase plasma tryptophan level and reduce geriatric depression scale score among older individuals who suffered from depression. Administration of 10 mg/kg BW eel's head powder was significant in increasing plasma tryptophan level and reducing GDS score.
抑郁症是主要问题之一，在老年人中的患病率更高。这一人群中抑郁症的潜在机制是多因素的，而抑郁症病理生理学中最重要的因素之一是大脑血清素水平。蛋白质缺乏与色氨酸缺乏有关，色氨酸是已知合成血清素的必需物质。这项随机对照试验旨在研究给予鳗鱼头粉对患有抑郁症的老年人群血浆色氨酸水平和老年抑郁量表（GDS）评分的有效性。受试者被分为三个干预组，分别给予为期2周、剂量为5mg/kg体重的鳗鱼头粉组、10mg/kg体重的鳗鱼头粉组和安慰剂组。10mg/kg体重组与5mg/kg体重组之间的血浆色氨酸水平和老年抑郁量表存在显著差异。给予10mg/kg体重鳗鱼头粉的组与接受安慰剂的组之间也存在显著差异；然而，5mg/kg体重鳗鱼头粉组与安慰剂组之间未发现此类差异。给予鳗鱼头粉可提高患有抑郁症的老年人的血浆色氨酸水平并降低老年抑郁量表评分。给予10mg/kg体重的鳗鱼头粉在提高血浆色氨酸水平和降低GDS评分方面具有显著意义。
