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伴有斜坡受累、神经症状及脑脊液蛋白45g/L的多发性骨髓瘤。

Multiple myeloma with clivus involvement, neurological symptoms, and 45 g/L proteinorachia.

作者信息

Chantran Yannick, Lavillegrand Jean-Rémi, Lefrere Bertrand, Gaillet Antoine, Aucouturier Pierre, Garderet Laurent

机构信息

Immunology Department Hôpital Saint-Antoine, AP-HP Paris France.

INSERM UMR_S 938 Immune System & Neuroinflammation Sorbonne Université Paris France.

出版信息

Clin Case Rep. 2019 Sep 30;8(1):5-8. doi: 10.1002/ccr3.2404. eCollection 2020 Jan.

DOI:10.1002/ccr3.2404
PMID:31998476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6982496/
Abstract

The mechanical obstruction of cerebrospinal fluid (CSF) flow can lead to very high hyperproteinorachia. In myeloma, tumoral clivus obstruction can cause such high proteinorachia, associated with paraprotein detection in the CSF in absence of intrathecal synthesis.

摘要

脑脊液（CSF）流动的机械性梗阻可导致蛋白含量极高的脑脊液。在骨髓瘤中，肿瘤性斜坡梗阻可导致如此高的脑脊液蛋白含量，并在脑脊液中检测到副蛋白，而不存在鞘内合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac95/6982496/3545fc9acd07/CCR3-8-5-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac95/6982496/3545fc9acd07/CCR3-8-5-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac95/6982496/3545fc9acd07/CCR3-8-5-g001.jpg

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Diagnostic utility of measuring free light chains in the cerebrospinal fluid of patients with multiple myeloma.
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