121例接受伽玛刀立体定向放射外科治疗作为局灶性复发性高级别胶质瘤挽救治疗患者的长期预后数据。
Long-term outcome data from 121 patients treated with Gamma Knife stereotactic radiosurgery as salvage therapy for focally recurrent high-grade gliomas.
作者信息
Smith Cody J, Fairres Marshall J, Myers Charlotte S, Chapple Kristina M, Klysik Michal, Karis John P, Youssef Emad, Smith Kris A
机构信息
College of Medicine, University of Arizona, Tucson, AZ, USA.
Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
出版信息
J Radiosurg SBRT. 2019;6(3):199-207.
INTRODUCTION
We examined patient outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) salvage therapy for recurrent high-grade gliomas (HGGs) to determine whether tumor grade or lesion size affected overall survival (OS) and progression-free survival (PFS).
METHODS
This single-center retrospective study assessed radiographic response and clinical outcomes following GKSRS salvage treatment of recurrent malignant gliomas (January 2005-March 2014).
RESULTS
A total of 121 patients (67 female) with 132 tumors were treated. Median (range) PFS was 4.7 (3.9-5.4) months for the cohort, 6.8 (4.6-8.9) months for initial grade 2 tumors, 4.2 (1.9-6.5) months for initial grade 3 tumors, and 4.3 (3.7-4.9) months for initial grade 4 tumors. Patients with small lesions (≤6.7 cm; n = 53) had significantly longer median (range) PFS (6.8 [4.8-8.8], P=0.02).
CONCLUSIONS
GKSRS offers meaningful salvage therapy with minimal morbidity in appropriately selected patients with focally recurrent HGGs.
引言
我们研究了伽玛刀立体定向放射外科手术（GKSRS）挽救性治疗复发性高级别胶质瘤（HGG）后的患者预后，以确定肿瘤分级或病变大小是否影响总生存期（OS）和无进展生存期（PFS）。
方法
这项单中心回顾性研究评估了GKSRS挽救性治疗复发性恶性胶质瘤后的影像学反应和临床结果（2005年1月至2014年3月）。
结果
共治疗了121例患者（67例女性），有132个肿瘤。该队列的中位（范围）PFS为4.7（3.9 - 5.4）个月，初始2级肿瘤为6.8（4.6 - 8.9）个月，初始3级肿瘤为4.2（1.9 - 6.5）个月，初始4级肿瘤为4.3（3.7 - 4.9）个月。病变较小（≤6.7 cm；n = 53）的患者中位（范围）PFS显著更长（6.8 [4.8 - 8.8]，P = 0.02）。
结论
对于经过适当选择的局灶性复发性HGG患者，GKSRS提供了具有最小发病率的有意义的挽救性治疗。
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