农药（农用化学品）毒理学评价的犬类一年重复剂量经口毒性研究综述（农药专家委员会决定，食品添加剂和食品接触材料安全委员会，2017年12月21日）
Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017).
出版信息
Food Saf (Tokyo). 2018 Dec 21;6(4):162-163. doi: 10.14252/foodsafetyfscj.2018008s. eCollection 2018 Dec.
Abstract
In the toxicological evaluation of pesticides (agricultural chemicals), their toxicities have been evaluated based on studies in rodents such as rats and mice as well as in non-rodents such as rabbits and dogs. Here, reflecting a research performed under the Food Safety Commission of Japan (FSCJ) grant on pesticide toxicity study, international trends and also scientific points of view, the necessity of chronic dog toxicity studies was reconsidered for the use in toxicological evaluation of pesticides.
摘要
在农药（农用化学品）的毒理学评估中，已基于对大鼠和小鼠等啮齿动物以及兔子和狗等非啮齿动物的研究来评估它们的毒性。在此，结合日本食品安全委员会（FSCJ）资助的农药毒性研究、国际趋势以及科学观点进行的一项研究，重新审视了慢性犬类毒性研究在农药毒理学评估中的必要性。
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