Aoki Yasunobu, Matsumoto Michiyo, Matsumoto Michi, Masumura Kenichi, Nohmi Takehiko
National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan.
National Institute of Health Sciences, Division of Genetics and Mutagenesis, Kawasaki, Japan.
Food Saf (Tokyo). 2019 Mar 13;7(1):2-10. doi: 10.14252/foodsafetyfscj.2018014. eCollection 2019 Mar.
The mutagenicity of hexavalent chromium in the small intestine, the target organ of tumorgenicity, was examined by means of a transgenic mouse gene mutation assay. Sodium dichromate dihydrate was administered orally in drinking water to male delta mice at a dose of 85.7 or 257.4 mg/L for 28 days or at a dose of 8.6, 28.6 or 85.7 mg/L for 90 days. No significant increase in mutant frequency relative to that in control mice was observed in the small intestine in either the 28- or 90-day study, whereas 28-day oral administration of potassium bromate, a positive control substance, increased mutant frequency.
通过转基因小鼠基因突变试验，研究了六价铬在致癌靶器官小肠中的致突变性。将二水合重铬酸钠以85.7或257.4mg/L的剂量口服给予雄性δ小鼠，持续28天；或以8.6、28.6或85.7mg/L的剂量口服给予雄性δ小鼠，持续90天。在28天或90天的研究中，小肠中相对于对照小鼠的突变频率均未观察到显著增加，而作为阳性对照物质的溴酸钾经口给药28天则增加了突变频率。
