Fox Lana, Hanley Christopher S, Padilla Luis R, Duncan Mary
Texas A&M Veterinary Medical Teaching Hospital, Department of Zoological Medicine, 408 Raymond Stotzer Parkway, College Station, TX 77845, USA.
Department of Animal Health, Saint Louis Zoo, One Government Drive, Saint Louis, MO 63110, USA.
Open Vet J. 2019 Oct;9(3):259-262. doi: 10.4314/ovj.v9i3.11. Epub 2019 Sep 11.
Teratomas are germ cell tumors, comprised of a mixture of tissue types and with tissue foreign to their site of origin.
A 5.5-year-old intact female maned wolf (Chrysocyon brachyurus) was treated for recurrent stranguria and suspected cystitis. Due to lack of resolution, the wolf was anesthetized for further evaluation. The urinary bladder was firm on palpation, with a markedly thickened wall and no observable lumen on ultrasound. Neoplastic infiltration was suspected on double contrast cystogram and confirmed via surgical exploration. The lesion was inoperable and the wolf was euthanized. Gross necropsy revealed two poorly distinguished masses infiltrating the urinary bladder dorsally and caudoventrally, with minimal remaining lumen. Histopathologic examination of the bladder and associated masses revealed a neoplasm comprised of multiple tissue types. Vascular invasion was noted.
The neoplasm was diagnosed as an extragonadal teratoma. Few extragonadal teratomas have been described and this is the first report of a teratoma originating in the urinary bladder of a non-human species.
畸胎瘤是生殖细胞肿瘤，由多种组织类型混合而成，且包含与其起源部位不同的组织。
一只5.5岁未绝育的雌性鬃狼（Chrysocyon brachyurus）因反复出现尿频和疑似膀胱炎接受治疗。由于病情未缓解，该鬃狼被麻醉以进行进一步评估。触诊时膀胱质地坚硬，壁明显增厚，超声检查未发现明显的管腔。双重对比膀胱造影怀疑有肿瘤浸润，并通过手术探查得以证实。该病变无法手术切除，这只鬃狼被实施安乐死。大体尸检显示有两个界限不清的肿块，分别向膀胱背侧和尾腹侧浸润，仅残留极少的管腔。对膀胱及相关肿块进行组织病理学检查发现肿瘤由多种组织类型组成。可见血管浸润。
该肿瘤被诊断为性腺外畸胎瘤。已报道的性腺外畸胎瘤很少，这是首例关于非人类物种膀胱起源的畸胎瘤的报告。
