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一种新型电磁-神经生物学接口,通过神经调节实现脊髓损伤中休眠运动神经根的功能激活。

A Novel Electromagnetic-Neurobiologic Interface for Functional Animation of Dormant Motor Nerve Roots in Spinal Cord Injury via Neuromodulation.

作者信息

Shah Jawad, Smith Richard H, Al-Gharaibeh Abeer

机构信息

Department of Neurosurgery, Insight Institute of Neurosurgery & Neuroscience, Flint, MI, United States.

Department of Research, Insight Institute of Neurosurgery & Neuroscience, Flint, MI, United States.

出版信息

Front Surg. 2020 Jan 10;6:73. doi: 10.3389/fsurg.2019.00073. eCollection 2019.

Abstract

Complete spinal cord injury is a devastating occurrence afflicting millions of people worldwide with no available treatment for functional motor recovery. In this report, we describe a procedure in which we used parts of a device available for chronic pain treatment to provide a neuromodulation of motor nerve roots in a case with complete motor and sensory paraplegia. By using a retrograde trans-foraminal approach to implant electrodes close to L2-S1 motor nerve roots bilaterally, we were able to stimulate those nerves and induce precise movements at the joints of lower extremity in a T5 complete spinal cord injury case. We believe that our approach shows potential of the device as a rehabilitation system with the possibility of a parallel electric circuitry that can bridge a damaged spinal cord.

摘要

完全性脊髓损伤是一种灾难性事件,全球数以百万计的人深受其害,目前尚无恢复功能性运动的有效治疗方法。在本报告中,我们描述了一种手术方法,即利用一种可用于慢性疼痛治疗的设备部件,对一名运动和感觉完全性截瘫患者的运动神经根进行神经调节。通过逆行经椎间孔入路,在双侧L2-S1运动神经根附近植入电极,我们能够刺激这些神经,并在一名T5完全性脊髓损伤患者的下肢关节处诱发精确运动。我们相信,我们的方法显示了该设备作为一种康复系统的潜力,其并行电路有可能连接受损的脊髓。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a78/6970190/e14d9a58f82b/fsurg-06-00073-g0001.jpg

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