Abell T L, Kim C H, Malagelada J R
Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905.
Mayo Clin Proc. 1988 Dec;63(12):1169-75. doi: 10.1016/s0025-6196(12)65401-9.
Eight patients (five men and three women) with previously unexplained recurrent cyclic episodes of nausea and vomiting are described. In these patients, the symptoms developed a mean of once every 3.2 months and persisted a mean of 3.5 days. None of the patients had an identifiable cause of their symptoms on conventional diagnostic tests. A detailed investigation of the gastrointestinal motility during an asymptomatic period revealed abnormal findings in all eight patients. Gastric hypomotility was substantiated in five patients, small bowel dysmotility in six, delayed gastric emptying in two, and gastric dysrhythmia in two. The data demonstrate that abnormal gastrointestinal motility occurs during an asymptomatic state in patients with cyclic episodes of nausea and vomiting. Because all patients with this syndrome had abnormal gastrointestinal motility but normal results of other gastrointestinal studies, idiopathic cyclic nausea and vomiting may be related to altered gastrointestinal motility.
本文描述了8例（5名男性和3名女性）既往病因不明的复发性周期性恶心和呕吐发作患者。这些患者症状平均每3.2个月发作1次，平均持续3.5天。所有患者经传统诊断检查均未发现症状的明确病因。在无症状期对胃肠动力进行的详细检查发现，所有8例患者均有异常表现。5例患者证实有胃动力不足，6例有小肠动力障碍，2例有胃排空延迟，2例有胃节律紊乱。数据表明，周期性恶心和呕吐发作的患者在无症状状态下会出现胃肠动力异常。由于所有患有该综合征的患者胃肠动力均异常，但其他胃肠检查结果正常，特发性周期性恶心和呕吐可能与胃肠动力改变有关。
