You C H, Chey W Y, Lee K Y, Menguy R, Bortoff A
Ann Intern Med. 1981 Oct;95(4):449-51. doi: 10.7326/0003-4819-95-4-449.
We describe a patient with symptoms of severe nausea, vomiting, epigastric bloating and pain, and marked weight loss due to a gastrointestinal motility disturbance. Motility abnormalities were characterized by uncoordinated high pressure (as high as 300 mm Hg) contractions and uncoordinated interdigestive motor complexes in the duodenum and small intestine, and tachygastria often associated with tachyarrhythmia in the gastric myoelectric activity recordings. Uncoordinated interdigestive myoelectric complexes again were found in the duodenum and small intestine. These abnormal myoelectric activities observed in the in-vivo study were confirmed in the in-vitro study. After distal hemigastrectomy and gastrojejunostomy, the symptoms of nausea, vomiting, and epigastric pain decreased considerably. Thus, the motility abnormality found in the study appears to be responsible for the symptoms described. This is probably a new clinical entity. The importance of manometric and myoelectric study of a gastrointestinal motility for unexplained nausea and vomiting is emphasized.
我们描述了一名因胃肠动力障碍出现严重恶心、呕吐、上腹胀和疼痛以及明显体重减轻症状的患者。动力异常的特征为十二指肠和小肠出现不协调的高压（高达300毫米汞柱）收缩以及不协调的消化间期运动复合波，并且在胃肌电活动记录中常伴有快速心律失常的快速胃动。在十二指肠和小肠中再次发现不协调的消化间期肌电复合波。体内研究中观察到的这些异常肌电活动在体外研究中得到了证实。远端半胃切除术和胃空肠吻合术后，恶心、呕吐和上腹部疼痛症状明显减轻。因此，该研究中发现的动力异常似乎是所描述症状的原因。这可能是一种新的临床实体。强调了对不明原因恶心和呕吐进行胃肠动力测压和肌电研究的重要性。
