慢性非炎性肌肉疼痛：中枢和外周介质
Chronic non-inflammatory muscle pain: central and peripheral mediators.
作者信息
Lesnak Joseph, Sluka Kathleen A
机构信息
Department of Physical Therapy and Rehabilitation Science, Pain Research Program, 1-242 MEB, University of Iowa, Iowa City, IA 52252, USA.
出版信息
Curr Opin Physiol. 2019 Oct;11:67-74. doi: 10.1016/j.cophys.2019.06.006. Epub 2019 Jun 18.
Conditions with chronic widespread non-inflammatory muscle pain, such as fibromyalgia, have complex etiologies with numerous proposed mechanisms for their pathophysiology of underlying chronic pain. Advancements in neuroimaging have allowed for the study of brain function and connectivity in humans with these conditions, while development of animal models have allowed for the study of both peripheral and central factors that lead to chronic pain. This article reviews the current literature surrounding the pathophysiology of chronic widespread non-inflammatory muscle pain focusing on both peripheral and central nervous system, as well as immune system, contributions to the development and maintenance of pain. A better understanding of the mechanisms underlying these conditions can allow for improvements in patient education, treatment and outcomes.
患有慢性广泛性非炎性肌肉疼痛的病症，如纤维肌痛，其病因复杂，对于潜在慢性疼痛的病理生理学有众多提出的机制。神经影像学的进展使得对患有这些病症的人类大脑功能和连通性进行研究成为可能，而动物模型的发展则使得对导致慢性疼痛的外周和中枢因素进行研究成为可能。本文回顾了围绕慢性广泛性非炎性肌肉疼痛病理生理学的当前文献，重点关注外周和中枢神经系统以及免疫系统对疼痛发生和维持的作用。更好地理解这些病症背后的机制可以改善患者教育、治疗和预后。
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