Multi-Mode adhesives performance and success/retention rates in NCCLs restorations: randomised clinical trial one-year report.

Compare clinical performance and success/retention rates of two multi-mode (MM) adhesives, applied in self-etch (SE) or etch-and-rinse (ER) modes, with SE-all-in-one adhesive (SE/SE with enamel etching) in NCCL restorations at one-year follow-up. Prospective, double-blind RCT approved by the University Fernando Pessoa and the National-Clinical-Research-Ethics Committees (CEIC-20150305), ClinicalTrials.gov registered (NCT02698371), in 38 participants with 210 restorations (AdmiraFusion) randomly allocated to six groups (Adhesives_Adhesion mode), each with 35 restorations: G1-Control FuturabondDC_SE; G2-Control FuturabondDC_SE with enamel etching; G3-FuturabondU_ER; G4-FuturabondU_SE; G5-AdheseUniversal_ER; G6-AdheseUniversal_SE. Restorations evaluated at baseline and one-year by three calibrated examiners (ICC ≥0.952) using FDI criteria and statistical analysis with nonparametric tests (alpha = 0.05). At one-year recall 36 participants, 199 restorations were available for examination; five (2.5%) restorations (G1  = 2; G2, G3, G4  = 1) were lost due to retention ( > .05); G1 showed less satisfying marginal adaptation ( < .05) than G2 and MM adhesives groups, particularly G6. Overall success rates ( > .05) were: 93.9% (G1), 97.0% (G2; G3; G4) and 100.0% (G5; G6). MM adhesives (FuturabondU and AdheseUniversal) showed similar and acceptable performance/success rates but also better clinical outputs than the SE-all-in-one adhesive (FuturabondDC), particularly in SE mode. Success and retention rates were similar and not dependent on materials or adhesion modes.