Epidemiology & Biostatistics, Western University, London, Ontario, Canada; Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada.
Computer Science, Western University, London, Ontario, Canada.
Epilepsy Behav. 2020 Mar;104(Pt A):106904. doi: 10.1016/j.yebeh.2020.106904. Epub 2020 Jan 27.
The objective of the study was to validate the parent-proxy reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) in a sample of young adults with a history of childhood-onset epilepsy, allowing for the utilization of a consistent informant (the parent) across the youths' stages of development. The 55-item (QOLCE-55) and 16-item versions (QOLCE-16) were evaluated.
Data came from 134 young adults (aged 18.0 to 28.5 years) with childhood-onset epilepsy, recruited through community and tertiary care centers across Canada. Confirmatory factor analysis (CFA) was used to assess the higher-order factor structure of the QOLCE. Cronbach's alpha was used to evaluate internal consistency. Convergent validity was assessed by intraclass correlation coefficients (ICC) with the youth self-reported Quality of Life in Epilepsy Questionnaire (QOLIE-31-P).
The higher-order factor structure of the QOLCE-55 and QOLCE-16 demonstrated adequate fit: QOLCE-55 comparative fit index (CFI) = 0.968, Tucker-Lewis index (TLI) = 0.966; and root mean square of approximation (RMSEA) = 0.061; QOLCE-16 CFI = 0.966, TFI = 0.959, RMSEA = 0.141. Higher-order factor loadings were strong, ranging from 0.71 to 0.90. Internal consistency was excellent for the total score (α = 0.97; α = 0.93) and good-excellent for each subscale (α > 78). Convergent validity was moderate to good for the total score (ICC > 0.72) and each subscale (ICC > 0.51).
These findings provide support for the use of the QOLCE-55 and QOLCE-16 among young adults with a history of childhood-onset epilepsy. Utilizing a consistent measure and informant across the stages of development is essential to reliably evaluate change over time.
本研究旨在验证父母-代理报告的儿童期癫痫生活质量问卷（QOLCE）在一组有儿童期起病癫痫病史的年轻成年人样本中的有效性，允许在年轻人的发展阶段使用一致的信息提供者（父母）。评估了 55 项（QOLCE-55）和 16 项版本（QOLCE-16）。
数据来自 134 名患有儿童期起病癫痫的年轻成年人（年龄 18.0 至 28.5 岁），他们通过加拿大各地的社区和三级保健中心招募。验证性因素分析（CFA）用于评估 QOLCE 的高阶因子结构。克朗巴赫的 alpha 用于评估内部一致性。通过与青年自我报告的癫痫生活质量问卷（QOLIE-31-P）的内类相关系数（ICC）评估聚合效度。
QOLCE-55 和 QOLCE-16 的高阶因子结构表现出良好的拟合度：QOLCE-55 比较拟合指数（CFI）=0.968，塔克-刘易斯指数（TLI）=0.966；以及均方根逼近（RMSEA）=0.061；QOLCE-16 的 CFI=0.966，TFI=0.959，RMSEA=0.141。高阶因子负荷较强，范围为 0.71 至 0.90。总分的内部一致性极好（α=0.97；α=0.93），每个分量表的内部一致性良好至极好（α>0.78）。总分（ICC>0.72）和每个分量表（ICC>0.51）的聚合效度为中等至良好。
这些发现为有儿童期起病癫痫病史的年轻成年人使用 QOLCE-55 和 QOLCE-16 提供了支持。在发展阶段使用一致的测量和信息提供者对于可靠地评估随时间的变化至关重要。
