Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
J Cardiovasc Pharmacol. 2020 Apr;75(4):284-291. doi: 10.1097/FJC.0000000000000803.
ELABELA (ELA), previously classified as a "noncoding" RNA, is a new endogenous peptidic ligand of apelin receptor (APJ/APLNR), a class A (rhodopsin-like) G protein-coupled receptor. It has been identified to play a crucial role in diverse biological processes, especially in the normal and pathological cardiovascular system. In comparison with APJ's first ligand apelin, ELA may play a key role at different time points or heart regions. In this review, we summarized the roles of the ELA-APJ signaling pathway in cardiovascular system development and diseases.
ELABELA (ELA)，以前被归类为“非编码”RNA，是一种新的内源性肽配体的阿片肽受体 (APJ/APLNR)，A 类 (视紫红质样) G 蛋白偶联受体。它已被确定在多种生物过程中发挥关键作用，特别是在正常和病理心血管系统。与 APJ 的第一个配体阿片肽相比，ELA 可能在不同的时间点或心脏区域发挥关键作用。在这篇综述中，我们总结了 ELA-APJ 信号通路在心血管系统发育和疾病中的作用。
