Wang Yan, Zhang Zhiming, Wang Jing, Zhang Xiaowei
Department of Gynecology.
Department of Clinical Laboratory, Xi'an Central Hospital.
Medicine (Baltimore). 2020 Jan;99(5):e18821. doi: 10.1097/MD.0000000000018821.
Though studies have shown association between C-reactive protein (CRP) level and the risk of ovarian cancer (OC), there have been some inconsistencies. The current metaanalysis was conducted to study the relationship between CRP and OC.
Three electronic databases of PubMed, Embase, and Cochrane Library were searched for prospective studies of OC from inception till May 2018. Relative risk (RR) was summarized using random-effects model, and the results of sensitivity, subgroup analyses, and publication biases were also calculated.
A total of 13 cohorts involving 1,852 OC patients were included for the final meta-analysis. The summary RRs indicated that high CRP was associated with an increased risk of all invasive OC (RR:1.36; 95% confidence interval [CI]:1.03-1.80; P = .032), while moderate CRP showed no significant impact on the risk of all invasive OC compared with low CRP (RR:1.17; 95% CI:0.97-1.41; P = .107). High (RR: 1.42; 95% CI: 0.85-2.37; P = .183) or moderate (RR: 1.29; 95% CI: 0.94-1.77; P = .119) CRP levels showed little or no effect on serous OC. Similarly, no significant differences for the comparisons of high versus low (RR: 1.82; 95% CI: 0.27-12.42; P = .540) or moderate versus low (RR: 0.72; 95% CI: 0.31-1.69; P = .455) CRP levels for the risk of mucinous OC were observed. Moreover, high (RR: 0.58; 95% CI: 0.13-2.54; P = .471) or moderate (RR: 0.81; 95% CI: 0.44-1.47; P = .484) CRP levels were not associated with the risk of endometrioid OC compared with low CRP levels.
High CRP levels were associated with increased risk of invasive OC. The risk of other OC types with CRP levels showed no association.
尽管研究表明C反应蛋白（CRP）水平与卵巢癌（OC）风险之间存在关联，但仍存在一些不一致之处。本荟萃分析旨在研究CRP与OC之间的关系。
检索了PubMed、Embase和Cochrane图书馆这三个电子数据库，以查找从开始到2018年5月的OC前瞻性研究。使用随机效应模型汇总相对风险（RR），并计算敏感性、亚组分析和发表偏倚的结果。
最终的荟萃分析共纳入了13个队列，涉及1852例OC患者。汇总RR表明，高CRP与所有侵袭性OC风险增加相关（RR：1.36；95%置信区间[CI]：1.03 - 1.80；P = 0.032），而与低CRP相比，中等CRP对所有侵袭性OC风险无显著影响（RR：1.17；95% CI：0.97 - 1.41；P = 0.107）。高（RR：1.42；95% CI：0.85 - 2.37；P = 0.183）或中等（RR：1.29；95% CI：0.94 - 1.77；P = 0.119）CRP水平对浆液性OC几乎没有或没有影响。同样，对于黏液性OC风险，高与低（RR：1.82；95% CI：0.27 - 12.42；P = 0.540）或中等与低（RR：0.72；95% CI：0.31 - 1.69；P = 0.455）CRP水平比较未观察到显著差异。此外，与低CRP水平相比，高（RR：0.58；95% CI：0.13 - 2.54；P = 0.471）或中等（RR：0.81；95% CI：0.44 - 1.47；P = 0.484）CRP水平与子宫内膜样OC风险无关。
高CRP水平与侵袭性OC风险增加相关。CRP水平与其他OC类型的风险无关联。
