Faculty of Medical Science, University of Kragujevac, Kragujevac, Serbia.
Clinical Pharmacology Department, Clinical Centre Kragujevac, Kragujevac, Serbia.
J Chemother. 2020 May;32(3):156-159. doi: 10.1080/1120009X.2020.1720342. Epub 2020 Jan 31.
Increased antibiotic utilization in hospital is linked to higher total treatment costs, together with increased length of stay, surgery and emergency admission. The aim of our retrospective cohort study was to investigate predictors of antibiotic utilization per single patient from an intensive care unit (ICU) of a tertiary care, university hospital in Serbia. Average utilization of antibiotics per patient was 23.9 ± 20.4 defined daily doses (DDDs). Diagnosis of systemic infection increased antibiotics utilization per patient for 10.0 DDDs, positive blood culture for 5.4 DDDs, isolation of spp. for 19.5 DDDs, isolation of spp. for 6.3 DDDs and injury for 7.3 DDDs per patient. Each new day of hospitalization and each additional drug prescribed increased utilization for further 0.3 DDDs and 1.2 DDDs, respectively. Appropriate and limited use of antibiotics in ICU is of key importance for preserving their effectiveness and decrease of bacterial resistance.
在医院中，抗生素的使用量增加与总治疗费用增加、住院时间延长、手术和急诊入院增加有关。我们的回顾性队列研究的目的是调查塞尔维亚一家三级护理、大学附属医院的重症监护病房（ICU）中每位患者抗生素使用量的预测因素。每位患者的平均抗生素使用量为 23.9±20.4 日治疗剂量（DDD）。全身性感染的诊断使每位患者的抗生素使用量增加 10.0 DDD，血培养阳性增加 5.4 DDD， 种分离增加 19.5 DDD， 种分离增加 6.3 DDD，损伤增加 7.3 DDD。住院天数每增加一天和开的药物每增加一种，抗生素的使用量分别增加 0.3 DDD 和 1.2 DDD。在 ICU 中合理、有限地使用抗生素对于保持其有效性和降低细菌耐药性至关重要。
