维生素 D 受体基因多态性与汉族人口口腔扁平苔藓易感性相关。
Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population.
机构信息
Department of Pediatric and Preventive dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Nanjing, 210029, China.
Department of oral mucosal disease, Affiliated Hospital of Stomatology, Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Nanjing, 210029, China.
出版信息
BMC Oral Health. 2020 Jan 30;20(1):26. doi: 10.1186/s12903-020-1002-3.
BACKGROUND
Vitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP.
METHODS
In total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the VDR gene were selected and genotyped.
RESULTS
The results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted Odd ratio(OR) = 2.68, 95% Confidence interval(CI) = 1.28-5.62, P = 0.009) and rs7975232 CC genotype (Recessive model: adjusted OR = 2.25, 95% CI = 1.10-4.58, P = 0.026). Moreover, rs2239185 and rs7975232 (P < 0.01) showed significant cumulative effects on OLP risk.Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR = 3.11, 95% CI = 1.42-6.83, P = 0.005), compared with the AC haplotype.
CONCLUSION
The rs2239185 and rs7975232 variants of VDR may influence OLP susceptibility, and VDR gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.
背景
维生素 D 受体（VDR）参与多种免疫介导的疾病，包括口腔扁平苔藓（OLP）。本研究旨在探讨 VDR 基因多态性与 OLP 发病风险的相关性。
方法
共纳入南京医科大学附属口腔医院的 177 例 OLP 患者和 207 例健康对照。选择 VDR 基因中的 8 个单核苷酸多态性（SNP：rs731236、rs739837、rs757343、rs2107301、rs2239185、rs7975232、rs11574129 和 rs11568820），并对其进行基因分型。
结果
结果显示，与 rs2239185 TT 基因型（隐性模型：调整后的优势比（OR）=2.68，95%置信区间（CI）=1.28-5.62，P=0.009）和 rs7975232 CC 基因型（隐性模型：调整后的 OR=2.25，95% CI=1.10-4.58，P=0.026）相比，OLP 发病风险增加。此外，rs2239185 和 rs7975232（P<0.01）的累积效应与 OLP 发病风险显著相关。单体型分析显示，与 AC 单体型相比，rs2239185-rs7975232 的 CC 单体型与 OLP 发病风险增加相关（OR=3.11，95% CI=1.42-6.83，P=0.005）。
结论
VDR 的 rs2239185 和 rs7975232 变异可能影响 OLP 的易感性，VDR 基因多态性可能是中国汉族人群 OLP 的候选易感区域。
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