Yamamoto Shiho, Nagamori Tsunehisa, Komatsu Shigetsuna, Shirai Masaru, Suzutani Tatsuo, Oki Junichi
Department of Pediatrics, Asahikawa Kosei Hospital, Japan.
Department of Pediatrics, Asahikawa Medical University, Japan.
Brain Dev. 2020 Apr;42(4):369-372. doi: 10.1016/j.braindev.2020.01.003. Epub 2020 Jan 27.
We present the case of an 8-month-old boy with the repeated recurrence of vesicles from the time of birth and who subsequently manifested psychomotor developmental delay. We retrospectively diagnosed the patient with congenital herpes simplex virus (HSV) infection. Computed tomography showed multiple calcifications in the periventricular white matter and thalami. The bilateral deep white matter showed an abnormally high signal intensity on T2-weighted magnetic resonance imaging. The patient required consecutive, suppressive therapy with valacyclovir to prevent the repeated recurrence of vesicles. This case presented a milder phenotype of congenital HSV infection in comparison to previous reports, and highlights the importance of the careful examination for this disease when neonates present with skin lesions.
我们报告了一名8个月大男童的病例，该患儿自出生起水疱反复复发，随后出现精神运动发育迟缓。我们回顾性诊断该患者为先天性单纯疱疹病毒（HSV）感染。计算机断层扫描显示脑室周围白质和丘脑有多处钙化。在T2加权磁共振成像上，双侧深部白质显示异常高信号强度。该患者需要连续使用伐昔洛韦进行抑制性治疗，以防止水疱反复复发。与先前的报告相比，该病例呈现出先天性HSV感染较轻的表型，并强调了新生儿出现皮肤病变时对该病进行仔细检查的重要性。
