Luu Khang, Nickles Emily, Schwarz Herbert
Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.
Oncoimmunology. 2019 Nov 3;9(1):1685301. doi: 10.1080/2162402X.2019.1685301. eCollection 2020.
New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases.
新证据表明CD137在控制爱泼斯坦-巴尔病毒（EBV）感染方面的重要性。（1）[此处原文缺失相关基因名称]中的突变易引发EBV相关疾病。（2）EBV诱导异位CD137表达，从而激活负反馈调节并减少T细胞共刺激。这些发现表明CD137激动剂可作为EBV相关疾病的新治疗方法。
