Shiryaev A A, Vasilyev A O, Zaitsev A V, Prilepskaya E A, Sazonova N A, Grigoryan I E, Kim Yu A, Pushkar D Yu
Department of Urology, Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov, Moscow, Russia.
Urologiia. 2019 Dec 31(6):131-136.
In modern clinical practice, antimicrobial resistance creates a significant problem for the effective metaphylaxis of various infectious and inflammatory diseases of the urinary system. Annually, researchers note an increasing number of mutations in the genomes of bacteria that cause infectious diseases, which leads to the appearance of more aggressive strains. The inefficiency of antibiotic therapy requires to a search for alternative methods for treatment and prevention of infectious diseases. use of viruses that infect bacteria (bacteriophages) represent one of such methods. A literature review of recent publications indicates that phage therapy has been gained significant increase. The general aspects of phage therapy, mechanism of action, as well as the existing possibilities and limitations of phage therapy in treatment and prevention of infectious diseases of the urinary system are highlighted in this article.
在现代临床实践中,抗生素耐药性给泌尿系统各种感染性和炎症性疾病的有效群体预防带来了重大问题。每年,研究人员都注意到导致传染病的细菌基因组中突变数量不断增加,这导致出现更具侵袭性的菌株。抗生素治疗的无效性要求寻找治疗和预防传染病的替代方法。使用感染细菌的病毒(噬菌体)就是其中一种方法。对近期出版物的文献综述表明,噬菌体疗法已得到显著发展。本文重点介绍了噬菌体疗法的一般方面、作用机制,以及噬菌体疗法在治疗和预防泌尿系统传染病方面的现有可能性和局限性。